INT238901

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.54
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
signal transducer activity (PTAFR)
Anatomy Link Frequency
IEC 1
platelet 1
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 35 92.36 High High
rheumatoid arthritis 30 64.08 Quite High
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 92.36 High High
Disease 21 90.84 High High
Cardiovascular Disease 14 80.80 Quite High
Increased Venous Pressure Under Development 14 80.16 Quite High
Neonatal Necrotizing Enterocolitis 34 76.72 Quite High
Dyslipidemia /

Combined Dyslipidemia

4 65.76 Quite High
Systemic Lupus Erythematosus 2 64.80 Quite High
Rheumatoid Arthritis 30 64.08 Quite High
Rheumatic Diseases 2 58.60 Quite High
Disorder Of Lipid Metabolism 17 29.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting and immunohistochemical analysis showed PAF induced STAT3 phosphorylation and nuclear translocation in IEC, and PAF-induced TLR4 expression was inhibited by STAT3 and NF?
Phosphorylation (phosphorylation) of PAF in IEC
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955554 Disease Relevance 0.32 Pain Relevance 0
One important mechanism by which oxLDL promotes immune activation is through platelet-activating factor (PAF), PAF-like lipids, and lysophosphatidylcholine in oxLDL which have PC as one determining epitope [42-44].
Phosphorylation (lysophosphatidylcholine) of platelet-activating factor in platelet
2) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453753 Disease Relevance 1.10 Pain Relevance 0.30

General Comments

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