INT238914

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 3.22
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

response to stress (CNR1, MAPK1) nucleoplasm (MAPK1) mitochondrion (MAPK1)
aging (CNR1) Golgi apparatus (MAPK1) DNA binding (MAPK1)
Anatomy Link Frequency
fibroblast 6
CNR1 (Homo sapiens)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 198 100.00 Very High Very High Very High
Osteoarthritis 178 100.00 Very High Very High Very High
Cannabinoid receptor 64 100.00 Very High Very High Very High
antagonist 18 97.52 Very High Very High Very High
Endocannabinoid 86 95.08 Very High Very High Very High
analgesia 2 60.00 Quite High
Multiple sclerosis 4 53.84 Quite High
Inflammation 66 51.08 Quite High
cannabis 8 48.88 Quite Low
Analgesic 6 37.52 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 198 100.00 Very High Very High Very High
Frailty 180 100.00 Very High Very High Very High
Synovitis 8 71.76 Quite High
Demyelinating Disease 4 53.84 Quite High
Disease 26 51.44 Quite High
INFLAMMATION 62 51.08 Quite High
Arthritis 18 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cannabinoid receptor stimulation of fibroblast-like cells from OA and RA patients produced a time-dependent phosphorylation of extracellular signal-regulated kinase (ERK)-1 and ERK-2 which was significantly blocked by the CB1 antagonist SR141716A.
Positive_regulation (stimulation) of Cannabinoid receptor in fibroblast Positive_regulation (dependent) of Phosphorylation (phosphorylation) of extracellular signal-regulated kinase in fibroblast associated with cannabinoid receptor, antagonist, rheumatoid arthritis and osteoarthritis
1) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2453762 Disease Relevance 1.61 Pain Relevance 1.17
Cannabinoid receptor stimulation of fibroblast-like cells from OA and RA patients produced a time-dependent phosphorylation of extracellular signal-regulated kinase (ERK)-1 and ERK-2 which was significantly blocked by the CB1 antagonist SR141716A.
Positive_regulation (stimulation) of Cannabinoid receptor in fibroblast Positive_regulation (produced) of Phosphorylation (phosphorylation) of extracellular signal-regulated kinase in fibroblast associated with cannabinoid receptor, antagonist, rheumatoid arthritis and osteoarthritis
2) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2453762 Disease Relevance 1.61 Pain Relevance 1.17

General Comments

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