INT238917

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.26
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CNR2) signal transducer activity (CNR2)
Anatomy Link Frequency
leucocytes 2
T-cells 1
CNR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 53 100.00 Very High Very High Very High
Cannabinoid 18 100.00 Very High Very High Very High
Osteoarthritis 89 99.24 Very High Very High Very High
rheumatoid arthritis 99 98.96 Very High Very High Very High
Endocannabinoid 205 97.92 Very High Very High Very High
antagonist 21 78.80 Quite High
analgesia 2 62.84 Quite High
Migraine 3 61.84 Quite High
Multiple sclerosis 6 56.68 Quite High
Inflammation 37 53.92 Quite High
Disease Link Frequency Relevance Heat
Frailty 90 99.24 Very High Very High Very High
Rheumatoid Arthritis 99 98.96 Very High Very High Very High
Vomiting 237 98.44 Very High Very High Very High
Stress 114 90.72 High High
Synovitis 4 74.60 Quite High
Disease 17 63.04 Quite High
Headache 3 61.84 Quite High
Cancer 6 58.96 Quite High
Demyelinating Disease 2 56.68 Quite High
INFLAMMATION 35 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cannabinoid-receptor 1 (CB1) but not cannabinoid-receptor 2 (CB2) mRNA expression in leucocytes 4 h after the experiment was significantly lower in volunteers with motion sickness than in participants without N&V.


Transcription ( mRNA expr) of CB2 in leucocytes associated with cannabinoid and vomiting
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2873996 Disease Relevance 0.99 Pain Relevance 0.27
Cannabinoid-receptor 1 (CB1) but not cannabinoid-receptor 2 (CB2) mRNA expression in leucocytes 4 h after the experiment was significantly lower in volunteers with motion sickness than in participants without N&V.


Transcription (expression) of cannabinoid-receptor 2 in leucocytes associated with cannabinoid and vomiting
2) Confidence 0.60 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2873996 Disease Relevance 1.00 Pain Relevance 0.27
14) but not with CB2 receptor mRNA (r?
Transcription (with) of CB2
3) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873996 Disease Relevance 0.70 Pain Relevance 0.12
In order to further analyze CBRs expression, we quantified the mRNA levels of the receptors in resting and anti-CD3/anti-CD28-stimulated T-cells; we found that CB2R mRNA was ?
Transcription (was) of CB2R in T-cells
4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0 Pain Relevance 0.08
CB1 and CB2 protein and RNA were present in the synovia of OA and RA patients.
Transcription (present) of CB2 protein associated with rheumatoid arthritis and osteoarthritis
5) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2453762 Disease Relevance 1.56 Pain Relevance 1.13
For example, upon interferon gamma treatment (primed state), BV2 cells increase both Cnr2 and Gpr55 mRNA levels, whereas with lipopolysaccharide treatment (activated state) these levels decrease [58].
Transcription (levels) of Cnr2 associated with cannabinoid receptor
6) Confidence 0.25 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0 Pain Relevance 0.09

General Comments

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