INT238920

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 9
Speculated 8
Reported most in Body
Documents 44
Total Number 53
Disease Relevance 27.86
Pain Relevance 10.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC9A3R2) nucleus (SLC9A3R2) protein complex assembly (SLC9A3R2)
cytoplasm (SLC9A3R2)
Anatomy Link Frequency
knee 18
quadriceps 1
cartilage 1
limb 1
SLC9A3R2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 2270 99.98 Very High Very High Very High
Pain 651 99.52 Very High Very High Very High
rheumatoid arthritis 99 99.20 Very High Very High Very High
Inflammation 81 96.64 Very High Very High Very High
Analgesic 51 95.76 Very High Very High Very High
Endocannabinoid 43 94.40 High High
palliative 48 91.68 High High
Arthritis 53 83.48 Quite High
agonist 4 73.32 Quite High
Cannabinoid 5 73.00 Quite High
Disease Link Frequency Relevance Heat
Knee Osteoarthritis 1922 99.98 Very High Very High Very High
Disease 402 99.98 Very High Very High Very High
Dislocations 84 99.96 Very High Very High Very High
Contracture 240 99.72 Very High Very High Very High
Pain 652 99.52 Very High Very High Very High
Frailty 488 99.34 Very High Very High Very High
Rheumatoid Arthritis 99 99.20 Very High Very High Very High
Obesity 386 99.16 Very High Very High Very High
Osteoarthritis 10 99.08 Very High Very High Very High
INFLAMMATION 79 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Younger patients with full knee ROM who have a higher self-perception of function are less likely to undergo TKA.
Spec (likely) Positive_regulation (undergo) of TKA in knee
1) Confidence 0.50 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.33 Pain Relevance 0.15
If these are the same clinical predictors that influence the decision to undergo TKA, then patients should be educated to the benefits of undergoing TKA prior to the onset of these severe limitations.
Positive_regulation (undergoing) of TKA
2) Confidence 0.50 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.37 Pain Relevance 0.20
The receiver operator characteristic cutoffs had the same result, with a strong ability to predict those who did not undergo TKA.
Neg (not) Positive_regulation (undergo) of TKA
3) Confidence 0.50 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.53 Pain Relevance 0.07
It is therefore more likely that an assessment of structural changes, functional ability and pain are collectively needed to accurately predict who will require TKA [7,24].
Positive_regulation (require) of TKA associated with pain
4) Confidence 0.50 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.50 Pain Relevance 0.25
Individuals younger than 60 years old who have full knee extension ROM are much less likely to undergo TKA.
Spec (likely) Positive_regulation (undergo) of TKA in knee
5) Confidence 0.50 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.55 Pain Relevance 0.07
Younger age, higher KOS-ADLS scores, faster TUG and SCT times, stronger quadriceps and full knee extension predicted those who do not undergo TKA.
Neg (not) Positive_regulation (undergo) of TKA in knee
6) Confidence 0.50 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.17 Pain Relevance 0
This suggests small reductions in end-range knee motion may significantly increase one's chance of requiring TKA in the future.
Positive_regulation (requiring) of TKA in knee
7) Confidence 0.50 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.49 Pain Relevance 0.13
Persons who underwent TKA were also significantly weaker in both the involved and uninvolved limb, had lower self-reported functional ability and had less knee extension than persons who did not undergo TKA.
Positive_regulation (underwent) of TKA in knee
8) Confidence 0.50 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.22 Pain Relevance 0
Collectively, these factors correctly predicted nearly all of those who did not undergo TKA within 2 years (91% correct prediction) but only slightly more than half (58% correct prediction) of those who did.
Neg (not) Positive_regulation (undergo) of TKA
9) Confidence 0.50 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.72 Pain Relevance 0.16
Therefore, a difference of ten to twenty points is not only clinically meaningful, but also dramatically increases the chance that one will undergo TKA.
Positive_regulation (undergo) of TKA
10) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.35 Pain Relevance 0.11
Persons that underwent TKA were also significantly weaker, had lower self-reported function and had less knee extension than persons who did not undergo TKA.
Positive_regulation (underwent) of TKA in knee
11) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2877653 Disease Relevance 0.49 Pain Relevance 0.20
Knowledge of the underlying clinical motivations of persons undergoing TKA is essential, as pre-operative factors affect post-operative outcomes.
Positive_regulation (undergoing) of TKA
12) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.49 Pain Relevance 0.25
In this study, age is also a strong predictor of TKA use once symptomatic end-stage knee OA has developed, with younger persons less likely to undergo TKA.
Spec (likely) Positive_regulation (undergo) of TKA in knee associated with osteoarthritis
13) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.52 Pain Relevance 0.13
The mean difference in age was relatively large between the two groups, with persons undergoing TKA being an average of six years older.
Positive_regulation (undergoing) of TKA
14) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.79 Pain Relevance 0.20
Persons that underwent TKA were also significantly weaker, had lower self-reported function and had less knee extension than persons who did not undergo TKA.
Neg (not) Positive_regulation (undergo) of TKA in knee
15) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2877653 Disease Relevance 0.47 Pain Relevance 0.18
No clear consensus exists on criteria to determine who should undergo TKA, however, severe pain, higher levels of disability and excessive cartilage degeneration appear to be decisive factors for the procedure [6,7].
Positive_regulation (undergo) of TKA in cartilage associated with pain
16) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.72 Pain Relevance 0.40
No clear consensus exists on criteria to determine who should undergo TKA.
Positive_regulation (undergo) of TKA
17) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2877653 Disease Relevance 0.96 Pain Relevance 0.52
Younger patients with full knee ROM who have a higher self-perception of function are less likely to undergo TKA.
Spec (likely) Positive_regulation (undergo) of TKA in knee
18) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2877653 Disease Relevance 0.22 Pain Relevance 0.03
Both regression models were better predictors of those who would not undergo TKA opposed to those who would undergo TKA.
Neg (not) Positive_regulation (undergo) of TKA
19) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.27 Pain Relevance 0.03
Currently, a longitudinal analysis of objective clinical measures that predict the decision to undergo TKA is lacking in the literature.
Positive_regulation (undergo) of TKA
20) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2877653 Disease Relevance 0.15 Pain Relevance 0.16

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