INT238985

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FGFR2) Golgi apparatus (FGFR2) cytoplasmic membrane-bounded vesicle (FGFR2)
plasma membrane (FGFR2) nucleus (FGFR2) cell-cell signaling (FGFR2)
Anatomy Link Frequency
cartilage 1
FGFR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 35 32.48 Quite Low
psoriasis 1 13.24 Low Low
cytokine 20 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Crohn's disease 5 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilic Esophagitis 106 98.64 Very High Very High Very High
Gastroesophageal Reflux Disease 36 96.72 Very High Very High Very High
Targeted Disruption 14 81.76 Quite High
Injury 9 60.64 Quite High
Disease 19 47.64 Quite Low
INFLAMMATION 38 32.48 Quite Low
Osteoarthritis 1 24.08 Low Low
Dermatitis 6 23.40 Low Low
Skin Diseases 5 22.36 Low Low
Psoriasis 7 13.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recombined allele was identified using primers FGFR2F5 and FGFR2rec (5?
Positive_regulation (primers) of FGFR2
1) Confidence 0.49 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.14 Pain Relevance 0
Recently, Mulder et al. found increased FGF-9 and FGF-Receptor expression levels in tissue from EoE subjects (n = 7) compared to HC (n = 7) and GERD (n = 7).
Positive_regulation (increased) of FGF-Receptor associated with gastroesophageal reflux disease and eosinophilic esophagitis
2) Confidence 0.22 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.05 Pain Relevance 0
The potent mitogenic effect of FGF2 in cartilage has previously been correlated with FGF receptor activation.
Positive_regulation (activation) of FGF receptor in cartilage
3) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453768 Disease Relevance 0 Pain Relevance 0

General Comments

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