INT239028

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.75
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Foxo4) enzyme binding (Foxo4) embryo development (Foxo4)
DNA binding (Foxo4) cytoplasm (Foxo4) cytosol (Foxo4)
Anatomy Link Frequency
erythrocyte 2
Foxo4 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 212 100.00 Very High Very High Very High
Inflammatory response 12 99.76 Very High Very High Very High
Arthritis 62 85.08 High High
Inflammation 46 79.52 Quite High
cytokine 38 72.00 Quite High
tolerance 6 58.80 Quite High
Infliximab 12 5.00 Very Low Very Low Very Low
abatacept 10 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 212 100.00 Very High Very High Very High
INFLAMMATION 52 99.36 Very High Very High Very High
Arthritis 66 85.08 High High
Apoptosis 22 80.80 Quite High
Autoimmune Disease 16 78.24 Quite High
Death 2 61.16 Quite High
Shock 4 56.84 Quite High
Stress 6 54.76 Quite High
Disease 30 33.56 Quite Low
Nicotine Addiction 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Forkhead box class O isoforms are expressed in RA synovial tissue, and a strong negative correlation between inactivation (phosphorylation) of Forkhead box class O 4 in RA synovial tissue and increased serum C-reactive protein levels and raised erythrocyte sedimentation rate in RA patients has been demonstrated [63,64].
Negative_regulation (inactivation) of Forkhead in erythrocyte associated with rheumatoid arthritis
1) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 1.33 Pain Relevance 0.57
The Forkhead box class O isoforms are expressed in RA synovial tissue, and a strong negative correlation between inactivation (phosphorylation) of Forkhead box class O 4 in RA synovial tissue and increased serum C-reactive protein levels and raised erythrocyte sedimentation rate in RA patients has been demonstrated [63,64].
Negative_regulation (inactivation) of Forkhead in erythrocyte associated with rheumatoid arthritis
2) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 1.42 Pain Relevance 0.59

General Comments

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