INT239037

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.69
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd28, Cd86)
Anatomy Link Frequency
CD86 2
dendritic cells 2
T-cell 2
macrophages 1
B cells 1
Cd28 (Mus musculus)
Cd86 (Mus musculus)
Pain Link Frequency Relevance Heat
abatacept 135 99.04 Very High Very High Very High
rheumatoid arthritis 250 95.88 Very High Very High Very High
psoriasis 3 94.32 High High
Infliximab 7 90.08 High High
cytokine 92 87.68 High High
methotrexate 27 81.60 Quite High
Leflunomide 1 76.28 Quite High
Inflammation 74 62.56 Quite High
Arthritis 104 50.20 Quite High
chemokine 18 44.16 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 29 98.64 Very High Very High Very High
Rheumatoid Arthritis 250 95.88 Very High Very High Very High
Psoriasis 3 94.32 High High
Disease 118 92.48 High High
Systemic Lupus Erythematosus 79 80.88 Quite High
Autoimmune Disease 72 71.60 Quite High
Death 6 63.20 Quite High
INFLAMMATION 81 62.56 Quite High
Renal Disease 28 53.52 Quite High
Shock 2 50.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because it binds to CD80 and CD86 with greater affinity than to CD28, it can outcompete CD28.
CD28 Binding (binds) of CD86 in CD86
1) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.17 Pain Relevance 0.24
A fusion protein comprised of CTLA4 fused to an immunoglobulin Fc portion (CTLA-4Ig), which binds to the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) and thus prevents CD28/B7 interaction and subsequent activation of the CD28 receptor on T cells, appears to be highly effective in treating RA.13 Although these data will have to be confirmed in further trials, not only do these results suggest that therapies directed at interfering with T-cell activities may be as effective as other DMARDs, but also that T cells are involved in the pathogenesis of RA.
CD28 Binding (interaction) of CD86 in T-cell associated with rheumatoid arthritis
2) Confidence 0.14 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2780633 Disease Relevance 0.69 Pain Relevance 0.40
Preferential engagement of CTLA-4, instead of CD28, with CD80/CD86 may provide a negative proliferative signal [78].
CD28 Binding (engagement) of CD86 in CD86
3) Confidence 0.13 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0 Pain Relevance 0.04
In APC/T cell co-cultures, mature dendritic cells (DC) were less efficient than immature DC in their ability to support Th17 cell differentiation, while CTLA4-Ig, an agent blocking CD28/B7 and CTLA4/B7 interactions, facilitated both murine and human Th17 differentiation.
CD28 Binding (interactions) of B7 in dendritic cells
4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2658739 Disease Relevance 0.14 Pain Relevance 0
CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.
CD28 Binding (binds) of CD86 in dendritic cells
5) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833980 Disease Relevance 0.46 Pain Relevance 0.12
Therefore a fusion protein of CTLA4 and immunoglobulin was constructed (CTLA4-Ig or abatacept and the successor belatacept which differs by only two amino acids) which has a higher affinity to CD28 than B7.
CD28 Binding (affinity) of B7 associated with abatacept
6) Confidence 0.10 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 0.65 Pain Relevance 0.46
CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.
CD28 Binding (binds) of CD86 in macrophages
7) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833980 Disease Relevance 0.46 Pain Relevance 0.12
CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.
CD28 Binding (binds) of CD86 in B cells
8) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833980 Disease Relevance 0.46 Pain Relevance 0.12
Abatacept inhibits activation of T cells by blocking the interaction between CD28 on T cells and B7 on antigen-presenting cells.
CD28 Binding (interaction) of B7 in T cells associated with abatacept
9) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.66 Pain Relevance 0.65

General Comments

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