INT239038

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.50
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd28, Cd86)
Anatomy Link Frequency
T-cell 4
dendritic cells 2
Cd28 (Mus musculus)
Cd86 (Mus musculus)
Pain Link Frequency Relevance Heat
abatacept 7 99.30 Very High Very High Very High
rheumatoid arthritis 144 95.88 Very High Very High Very High
Infliximab 6 90.08 High High
cytokine 55 87.68 High High
methotrexate 3 81.60 Quite High
Leflunomide 1 76.28 Quite High
Inflammation 45 62.56 Quite High
Arthritis 60 50.20 Quite High
chemokine 10 44.16 Quite Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 144 95.88 Very High Very High Very High
Disease 26 92.48 High High
Autoimmune Disease 34 71.96 Quite High
INFLAMMATION 52 62.56 Quite High
Shock 2 51.32 Quite High
Arthritis 64 50.20 Quite High
Adhesions 2 39.20 Quite Low
Bacterial Infection 1 11.40 Low Low
Apoptosis 17 5.00 Very Low Very Low Very Low
Multiple Sclerosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A fusion protein comprised of CTLA4 fused to an immunoglobulin Fc portion (CTLA-4Ig), which binds to the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) and thus prevents CD28/B7 interaction and subsequent activation of the CD28 receptor on T cells, appears to be highly effective in treating RA.13 Although these data will have to be confirmed in further trials, not only do these results suggest that therapies directed at interfering with T-cell activities may be as effective as other DMARDs, but also that T cells are involved in the pathogenesis of RA.
Negative_regulation (prevents) of CD28 Binding (interaction) of CD86 in T-cell associated with rheumatoid arthritis
1) Confidence 0.17 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2780633 Disease Relevance 0.69 Pain Relevance 0.40
In APC/T cell co-cultures, mature dendritic cells (DC) were less efficient than immature DC in their ability to support Th17 cell differentiation, while CTLA4-Ig, an agent blocking CD28/B7 and CTLA4/B7 interactions, facilitated both murine and human Th17 differentiation.
Negative_regulation (blocking) of CD28 Binding (interactions) of B7 in dendritic cells
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2658739 Disease Relevance 0.14 Pain Relevance 0
Abatacept inhibits activation of T cells by blocking the interaction between CD28 on T cells and B7 on antigen-presenting cells.
Negative_regulation (blocking) of CD28 Binding (interaction) of B7 in T cells associated with abatacept
3) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.67 Pain Relevance 0.65

General Comments

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