INT239050

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 15.00
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Mbl1) extracellular region (Mbl1)
Anatomy Link Frequency
plasma 3
joint 1
juvenile 1
apoptotic cells 1
Mbl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 136 99.40 Very High Very High Very High
rheumatoid arthritis 935 99.36 Very High Very High Very High
ischemia 17 97.56 Very High Very High Very High
Arthritis 255 93.44 High High
spinal inflammation 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 119 99.40 Very High Very High Very High
Rheumatoid Arthritis 935 99.36 Very High Very High Very High
Disease 493 99.00 Very High Very High Very High
Diabetes Mellitus 17 98.84 Very High Very High Very High
Arthritis 357 98.72 Very High Very High Very High
Reperfusion Injury 17 98.32 Very High Very High Very High
Systemic Lupus Erythematosus 17 98.32 Very High Very High Very High
Infection 102 98.24 Very High Very High Very High
Coronary Artery Disease 34 97.56 Very High Very High Very High
Apoptosis 17 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, intermediately decreased MBL serum levels are seen in individuals with the genotypes XA/XA and YA/O, whereas very low or undetectable serum MBL levels are seen in individuals with genotypes XA/O and O/O.
Negative_regulation (decreased) of MBL
1) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.17 Pain Relevance 0.03
Although unproven, it has been hypothesized that infection may trigger JRA in genetically susceptible patients [26]; this viewpoint suggests that MBL deficiency can predispose to JRA.
Negative_regulation (deficiency) of MBL associated with rheumatoid arthritis and infection
2) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.13 Pain Relevance 0.36
The mechanism by which MBL deficiency might promote inflammation in immune-mediated inflammatory diseases such as RA and JRA is as yet unknown.
Negative_regulation (deficiency) of MBL associated with inflammation, rheumatoid arthritis and disease
3) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.34 Pain Relevance 0.40
On the other hand, MBL deficiency might be associated with defective clearance of immune complexes and apoptotic cells, as seen in individuals with C1q deficiency.
Negative_regulation (deficiency) of MBL in apoptotic cells associated with apoptosis
4) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.39 Pain Relevance 0.33
It has also been suggested that MBL deficiency is associated with joint erosions and early disease onset of adult rheumatoid arthritis (RA) [19-23], although other investigators were unable to confirm such an association [24,25].
Negative_regulation (deficiency) of MBL in joint associated with rheumatoid arthritis and disease
5) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.94 Pain Relevance 0.24
In the case of MBL deficiency, potential explanations for this younger age at onset are increased susceptibility to infections, as a potential trigger of polyarthritis, or ineffective clearance of infectious agents in the pathophysiology of JRA.
Negative_regulation (deficiency) of MBL associated with rheumatoid arthritis, arthritis and infection
6) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.50 Pain Relevance 0.31
MBL deficiency has been associated with increased susceptibility to and severity of infections, especially in children [15,16].
Negative_regulation (deficiency) of MBL associated with infection
7) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.55 Pain Relevance 0.11
MBL deficiency might lead to a diminished innate immunity, and subsequent increased risk for infections, as was previously remonstrated [15,16].
Negative_regulation (deficiency) of MBL associated with infection
8) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.41 Pain Relevance 0.43
Based on the number of included patients and control individuals, this study has 80% power when an odds ratio of 1.71 or greater for MBL deficiency is found.
Negative_regulation (deficiency) of MBL
9) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.99 Pain Relevance 0.35
In this study we demonstrated that the frequency of MBL deficiency was not increased in 218 Norwegian Caucasian children with JRA as compared with 194 Dutch Caucasian control individuals.
Negative_regulation (deficiency) of MBL associated with rheumatoid arthritis
10) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.47 Pain Relevance 0.17
Reduced or deficient MBL plasma levels are seen in individuals with heterozygous or homozygous SNPs in codons 54 (B mutation), 52 (D mutation), or 57 (C mutation) of exon 1 of the MBL2 gene [5,8,9].
Negative_regulation (Reduced) of MBL in plasma
11) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.57 Pain Relevance 0.22
The frequency of MBL deficiency was similar in JRA patients and control individuals (odds ratio 1.1, 95% confidence interval 0.9 to 1.4; P = 0.37).
Negative_regulation (deficiency) of MBL associated with rheumatoid arthritis
12) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.92 Pain Relevance 0.36
However, only the X/Y variant has a pronounced influence; the X allele is associated with decreased plasma MBL levels and the Y variant with high plasma MBL levels.
Negative_regulation (decreased) of MBL in plasma
13) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.05 Pain Relevance 0
Genetically determined MBL deficiency does not increase susceptibility to JRA, but MBL deficiency is associated with a younger age at onset of juvenile polyarthritis.
Negative_regulation (deficiency) of MBL in juvenile associated with rheumatoid arthritis and arthritis
14) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2453777 Disease Relevance 0.59 Pain Relevance 0.13
In this regard, lack of the protein MBL in serum appears to be associated with a milder disease course or decreased inflammation.
Negative_regulation (lack) of MBL associated with inflammation and disease
15) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.07 Pain Relevance 0.34
Reduced or deficient MBL plasma levels are seen in individuals with heterozygous or homozygous SNPs in codons 54 (B mutation), 52 (D mutation), or 57 (C mutation) of exon 1 of the MBL2 gene [5,8,9].
Negative_regulation (deficient) of MBL in plasma
16) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.57 Pain Relevance 0.22
Genetically determined MBL deficiency does not increase susceptibility to JRA, but MBL does appear to have an immunomodulating effect.
Negative_regulation (deficiency) of MBL associated with rheumatoid arthritis
17) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.35 Pain Relevance 0.26

General Comments

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