INT239060

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.89
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Mbl1) extracellular region (Mbl1)
Anatomy Link Frequency
joints 1
erythrocyte 1
Mbl1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 220 98.58 Very High Very High Very High
Arthritis 60 96.28 Very High Very High Very High
Inflammation 44 92.92 High High
ischemia 24 83.04 Quite High
antagonist 5 5.00 Very Low Very Low Very Low
spinal inflammation 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 116 99.76 Very High Very High Very High
Rheumatoid Arthritis 220 98.58 Very High Very High Very High
Arthritis 84 98.52 Very High Very High Very High
Apoptosis 5 96.56 Very High Very High Very High
Uveitis 12 93.44 High High
INFLAMMATION 40 92.92 High High
Cv Unclassified Under Development 16 83.04 Quite High
Injury 37 79.72 Quite High
Infection 24 77.28 Quite High
Juvenile Chronic Polyarthritis 32 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MBL association with disease parameters
MBL Binding (association) of associated with disease
1) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.82 Pain Relevance 0.17
Furthermore, MBL deficiency does not appear to play a role once polyarthritis has developed, because no associations were found between MBL2 genotype and the laboratory variables or the remaining disease severity related clinical variables, such as PGA, CHAQ score, number of actively involved or affected joints, and number of patients with uveitis or remission.
MBL Binding (deficiency) of in joints associated with uveitis, disease and arthritis
2) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.51 Pain Relevance 0.47
If we are to discover the possible contribution of MBL to JRA disease severity, then we must study molecular mechanisms such as the interaction of MBL with immune complexes, the presence of anti-MBL autoantibodies and the role of activation of the complement system.


MBL Binding (interaction) of associated with rheumatoid arthritis and disease
3) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.37 Pain Relevance 0.42
The lectin pathway is initiated by recognition of exposed carbohydrates/ligands by mannose-binding lectin (MBL) and/or ficolins (Figure 1 (Fig. 1)) [10], [11].
MBL Binding (recognition) of
4) Confidence 0.27 Published 2010 Journal GMS German Medical Science Section Body Doc Link PMC2940219 Disease Relevance 0.59 Pain Relevance 0.14
We did not find any association of MBL genotype groups with other clinical features, such as number of cumulative affected joints, arthritis severity index, PGA, CHAQ scores, or number of patients with uveitis, remission, or severe radiographic erosions, or with laboratory tests such as ANAs, erythrocyte sedimentation rate, and IgM-RF (Table 3).
MBL Neg (not) Binding (association) of in erythrocyte associated with uveitis and arthritis
5) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.60 Pain Relevance 0.07

General Comments

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