INT239093

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 7
Reported most in Body
Documents 84
Total Number 91
Disease Relevance 83.94
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTTG1) mitosis (PTTG1) chromosome organization (PTTG1)
chromosome segregation (PTTG1) nucleus (PTTG1) cell division (PTTG1)
Anatomy Link Frequency
pituitary 6
colon 6
thyroid 4
A549 4
ovary 4
PTTG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 93 93.56 High High
metalloproteinase 793 90.36 High High
Inflammation 91 88.92 High High
Kinase C 88 87.52 High High
agonist 3 71.88 Quite High
Dopamine 5 71.56 Quite High
imagery 103 61.84 Quite High
Central nervous system 88 5.00 Very Low Very Low Very Low
Somatostatin 23 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2376 99.96 Very High Very High Very High
Hepatocellular Cancer 352 99.96 Very High Very High Very High
Pituitary Cancer 1236 99.92 Very High Very High Very High
Cancer 7790 99.86 Very High Very High Very High
Apoptosis 1590 99.80 Very High Very High Very High
Adenoma 292 99.76 Very High Very High Very High
Anaplastic Astrocytoma 88 99.60 Very High Very High Very High
Esophageal Cancer 176 99.56 Very High Very High Very High
Hyperplasia 446 99.52 Very High Very High Very High
Ovarian Cancer 1408 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This latter gene (a securin homolog) is over-expressed in functional pituitary tumors, which could lead to aneuploidy [45]; the degree of over-expression correlates with tumor size and invasiveness.
Gene_expression (expressed) of securin in pituitary associated with aneuploidy, cancer and pituitary cancer
1) Confidence 0.65 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 1.28 Pain Relevance 0
The expression of PTTG1 in normal tissues is restricted and found to be highly expressed in the testis in a stage-specific manner during the spermatogenesis.
Gene_expression (expression) of PTTG1 in testis
2) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.39 Pain Relevance 0
Dominguez et al. [9] showed that human PTTG1 is mainly present in the cytoplasm (85%) in Jurkat cells by subcellular fractionation.
Gene_expression (present) of PTTG1
3) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0 Pain Relevance 0
These investigators also observed the median survival time (8.5 months) for patients with high PTTG1 expression levels compared to the survival time (14.0 months) for patients with low PTTG1 expression levels, suggesting a role of PTTG1 in metastasis.
Gene_expression (expression) of PTTG1 associated with metastasis
4) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.34 Pain Relevance 0.09
High levels of PTTG1 expression have been reported in a variety of tumors.
Gene_expression (expression) of PTTG1 associated with cancer
5) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.40 Pain Relevance 0
Based on these experiments, these investigators concluded that aneuploidy was not the cause of apoptosis in these PTTG1 overexpressing cells since the majority of cells were not aneuploid before they entered apoptosis.
Gene_expression (overexpressing) of PTTG1 associated with aneuploidy and apoptosis
6) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.75 Pain Relevance 0
Although the expression levels of PTTG1 are restricted in normal cells, elevated expressions of PTTG1 were observed in many tumors including carcinomas of the lung, breast, colon, and ovary, leukemia and lymphoma, and also in pituitary adenomas [6,9,11,13,15,18,25].
Gene_expression (expression) of PTTG1 in colon associated with leukemia, lymphatic system cancer, cancer, pituitary cancer and carcinoma
7) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.76 Pain Relevance 0
This also suggests that PTTG1 overexpression in transgenic mice affects early pituitary multipotential cells or may influence neighboring non-?
Gene_expression (overexpression) of PTTG1 in pituitary associated with targeted disruption
8) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.55 Pain Relevance 0.04
Although the expression levels of PTTG1 are restricted in normal cells, elevated expressions of PTTG1 were observed in many tumors including carcinomas of the lung, breast, colon, and ovary, leukemia and lymphoma, and also in pituitary adenomas [6,9,11,13,15,18,25].
Gene_expression (expressions) of PTTG1 in colon associated with leukemia, lymphatic system cancer, cancer, pituitary cancer and carcinoma
9) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.78 Pain Relevance 0
Zhang et al. [11] investigated the expression levels of PTTG1 in many normal and cancerous cells and found that PTTG1 is expressed in normal adult testis, thymus, colon, small intestine, brain, lung, and fetal liver.
Gene_expression (expressed) of PTTG1 in adult testis
10) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.20 Pain Relevance 0.03
As reported above, PTTG1 is found to be overexpressed in most of the ovarian tumors analyzed to date and the PTTG1 promoter is specifically activated in tumor cells, including OSE tumor cells.
Gene_expression (overexpressed) of PTTG1 in OSE associated with cancer and ovarian cancer
11) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.21 Pain Relevance 0
Zhang et al. [11] investigated the expression levels of PTTG1 in many normal and cancerous cells and found that PTTG1 is expressed in normal adult testis, thymus, colon, small intestine, brain, lung, and fetal liver.
Spec (investigated) Gene_expression (expression) of PTTG1 in adult testis
12) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.23 Pain Relevance 0.03
To evaluate the oncogenic function of PTTG1 and its ability to transform OSE cells, we generated transgenic animals that express PTTG1 in OSE cells under the control of the MISIIR gene promoter [6].
Gene_expression (express) of PTTG1 in OSE associated with targeted disruption
13) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.34 Pain Relevance 0
The mRNA and protein of PTTG1 expression was significantly reduced by treatment with siRNA.
Gene_expression (expression) of PTTG1
14) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.91 Pain Relevance 0
Nude mice injected with A2780 cells expressing PTTG1-siRNA showed a decrease in tumor development and growth [100].


Gene_expression (expressing) of PTTG1 in A2780 associated with cancer
15) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.06 Pain Relevance 0
These investigators silenced PTTG1 expression in human A2780 OCA cells and investigated the effect on tumor formation in vitro and in vivo.
Gene_expression (expression) of PTTG1 in A2780 associated with cancer and ovarian cancer
16) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.79 Pain Relevance 0
We also observed the overexpression of PTTG1 in tissues of ovarian cancer from different patients (Figure. 5).
Gene_expression (overexpression) of PTTG1 associated with ovarian cancer
17) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.18 Pain Relevance 0
Consistent with these observations, Ramaswamy et al. [79] reported a correlation between expression levels of PTTG1 with metastatic adenocarcinomas using microarray analysis.
Gene_expression (expression) of PTTG1 associated with adenocarcinoma
18) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.48 Pain Relevance 0.13
Increases in pituitary hyperplasia in PTTG1 overexpressing cells were observed in these bitransgenic mice when compared to Rb+/- mice, supporting a role of PTTG1 in pituitary gland tumorigenesis.
Gene_expression (overexpressing) of PTTG1 in pituitary gland associated with pituitary cancer
19) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.04 Pain Relevance 0
Moreover, the expression levels of PTTG1 increased during cell proliferation and in mitosis in a cell cycle-dependent manner, which indicates its role in regulation of the cell cycle [53].
Gene_expression (expression) of PTTG1
20) Confidence 0.31 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.65 Pain Relevance 0

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