INT239094

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.61
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GH1) extracellular region (GH1)
Anatomy Link Frequency
pituitary 2
GH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 3 57.92 Quite High
imagery 12 13.84 Low Low
Somatostatin 18 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 4 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 9 99.52 Very High Very High Very High
Acromegaly 83 99.28 Very High Very High Very High
Cancer 38 98.50 Very High Very High Very High
Laron Syndrome 15 97.14 Very High Very High Very High
Disease 17 80.20 Quite High
Liver Disease 2 74.60 Quite High
Recurrence 2 74.52 Quite High
Nutritional Deficiencies 5 73.96 Quite High
Pituitary Cancer 18 73.56 Quite High
Adenoma 30 60.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumor excision, usually by the trans-sphenoidal route, is the most rapid way of reducing GH and IGF-I concentrations in patients with acromegaly.
Negative_regulation (reducing) of GH Binding (concentrations) of associated with acromegaly and cancer
1) Confidence 0.34 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 0.83 Pain Relevance 0.06
Otherwise, primary GHI or IGFD is due to congenital resistance to GH action with low or absent peripheral IGF-1.2 This syndrome, also known as Laron syndrome, was first described by Laron in the late 1960s as pituitary dwarfisms with high serum GH.2 It is a very rare syndrome resulting from genetic abnormality of GH receptor, mainly occurring in patients with high consanguinity.2,5
Negative_regulation (abnormality) of GH Binding (receptor) of in pituitary associated with laron syndrome and syndrome
2) Confidence 0.21 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.78 Pain Relevance 0

General Comments

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