INT239095

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 8.24
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTTG1) mitosis (PTTG1) chromosome organization (PTTG1)
chromosome segregation (PTTG1) nucleus (PTTG1) cell division (PTTG1)
Anatomy Link Frequency
MCF-7 1
pituitary 1
PTTG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 72 69.76 Quite High
Pain 13 18.88 Low Low
imagery 20 5.00 Very Low Very Low Very Low
Somatostatin 17 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 122 99.92 Very High Very High Very High
Hepatocellular Cancer 32 99.78 Very High Very High Very High
Apoptosis 144 99.64 Very High Very High Very High
Cancer 732 98.88 Very High Very High Very High
Hyperplasia 44 97.52 Very High Very High Very High
Thrombocytopenia 8 96.84 Very High Very High Very High
Adenoma 46 94.04 High High
Ovarian Cancer 128 93.52 High High
Liver Cancer 24 92.68 High High
Targeted Disruption 216 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the pituitary, loss of heterozygosity on chromosomes 11, 13 and 9 (particularly in invasive macroadenomas), and an activating gene (PTTG, pituitary tumor transforming gene), also play a role.
Negative_regulation (loss) of PTTG in pituitary associated with pituitary cancer
1) Confidence 0.32 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 1.15 Pain Relevance 0
These results indicate that downregulation of PTTG1 using PTTG1 siRNA inhibits tumors grown in vitro and in vivo.
Negative_regulation (downregulation) of PTTG1 associated with cancer
2) Confidence 0.23 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.63 Pain Relevance 0
We also found that there was almost a 60% reduction in PTTG1 protein after two days of transfection.
Negative_regulation (reduction) of PTTG1
3) Confidence 0.23 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.87 Pain Relevance 0
Therefore, down-regulation of PTTG1 or inactivation of its tumorgenic function in cancer may become an important target in developing new cancer therapies.



Negative_regulation (regulation) of PTTG1 associated with cancer
4) Confidence 0.17 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.50 Pain Relevance 0
The mice lacking PTTG1 were found to have testicular and splenic hypoplasia, thymic hyperplasia, and thrombocytopenia.
Negative_regulation (lacking) of PTTG1 associated with thrombocytopenia and hyperplasia
5) Confidence 0.17 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.65 Pain Relevance 0
Suppression of PTTG1 with siRNA a 2-fold induction of TSP-1 was observed.
Negative_regulation (Suppression) of PTTG1
6) Confidence 0.17 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.19 Pain Relevance 0
In their experiment, they showed that PTTG1 serves as a negative regulator of p53 tumor suppression in hepatocellular carcinoma (HCC) and that depletion of PTTG1 significantly inhibits growth of PTTG1-overexpressing HCC cell lines in vitro and in vivo.
Negative_regulation (depletion) of PTTG1 associated with cancer and hepatocellular cancer
7) Confidence 0.17 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.19 Pain Relevance 0
In their experiments, they also observed that the dominant negative p53 mutant did not inhibit PTTG1-induced apoptosis in MCF-7 cells.
Negative_regulation (inhibit) of PTTG1 in MCF-7 associated with apoptosis
8) Confidence 0.17 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.41 Pain Relevance 0.09
PTTG1 siRNA was successful in downregulating PTTG1 as well as Ki67, bFGF, and CD34 in H1299 tumors in nude mice.
Negative_regulation (downregulating) of PTTG1 associated with cancer
9) Confidence 0.15 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.66 Pain Relevance 0

General Comments

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