INT2391

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 0
Speculated 9
Reported most in Abstract
Documents 501
Total Number 510
Disease Relevance 207.62
Pain Relevance 205.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
platelet 25
blood 15
monocyte 10
plasma 8
colon 7
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2563 100.00 Very High Very High Very High
Inflammation 1205 100.00 Very High Very High Very High
COX2 327 100.00 Very High Very High Very High
Paracetamol 305 100.00 Very High Very High Very High
cytokine 249 100.00 Very High Very High Very High
acular 173 100.00 Very High Very High Very High
cOX1 149 100.00 Very High Very High Very High
Potency 109 100.00 Very High Very High Very High
Central nervous system 33 100.00 Very High Very High Very High
monoamine 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1919 100.00 Very High Very High Very High
Cancer 1116 100.00 Very High Very High Very High
Disease 609 99.92 Very High Very High Very High
Breast Cancer 216 99.92 Very High Very High Very High
Pain 847 99.88 Very High Very High Very High
Renal Disease 23 99.84 Very High Very High Very High
Colon Cancer 286 99.68 Very High Very High Very High
Hypersensitivity 96 99.66 Very High Very High Very High
Hemorrhage 168 99.64 Very High Very High Very High
Cv Unclassified Under Development 47 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase inhibition attenuates sympathetic responses to muscle stretch in humans.
Negative_regulation (inhibition) of Cyclooxygenase in sympathetic
1) Confidence 0.59 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 18441194 Disease Relevance 0.33 Pain Relevance 0.35
Thus we hypothesized that local cyclooxygenase inhibition in exercising muscles could attenuate MSNA responses to passive muscle stretch during PEMI.
Negative_regulation (inhibition) of cyclooxygenase in muscles associated with ischemia
2) Confidence 0.59 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18441194 Disease Relevance 0.35 Pain Relevance 0.36
Blood pressure (Finapres), heart rate, and MSNA (microneurography) responses to passive muscle stretch were assessed in 13 young healthy subjects during PEMI before and after cyclooxygenase inhibition, which was accomplished by a local infusion of 6 mg ketorolac tromethamine in saline via Bier block.
Negative_regulation (inhibition) of cyclooxygenase in muscle associated with ischemia and acular
3) Confidence 0.59 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18441194 Disease Relevance 0.34 Pain Relevance 0.50
Increased intestinal permeability is shown to be related to drug potency to inhibit cyclooxygenase and the effect is systemically mediated rather than a local irritant one.
Negative_regulation (inhibit) of cyclooxygenase associated with potency
4) Confidence 0.59 Published 1987 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 3324305 Disease Relevance 0.42 Pain Relevance 0.63
Therefore, the nonsteroidal anti-inflammatory drugs and aspirin, which inhibit cyclooxygenase, might be expected to reduce cerebral blood flow and the response to hypercapnia.
Negative_regulation (inhibit) of cyclooxygenase in blood associated with aspirin, inflammation and hypercapnia
5) Confidence 0.59 Published 1994 Journal Stroke Section Abstract Doc Link 8073456 Disease Relevance 0.29 Pain Relevance 0.19
Experimental evidence indicates that renal prostaglandin and thromboxane production is increased in several models of renal disease and that similar decrements in renal function occur with cyclooxygenase inhibition and may be due to inhibition of vasodilator prostaglandins.
Negative_regulation (inhibition) of cyclooxygenase associated with renal disease
6) Confidence 0.59 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3080878 Disease Relevance 0.52 Pain Relevance 0.09
The possibility of adverse effects on renal function in certain patients with renal disease due to cyclooxygenase inhibition with nonsteroidal anti-inflammatory drugs has long been appreciated.
Negative_regulation (inhibition) of cyclooxygenase associated with inflammation, renal disease and cinod
7) Confidence 0.59 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3080878 Disease Relevance 0.48 Pain Relevance 0.10
There is experimental evidence that inhibition of cyclooxygenase with nonsteroidal anti-inflammatory drugs may decrease cholesterol gallstone formation and mitigate biliary pain in gallstone patients.
Negative_regulation (inhibition) of cyclooxygenase associated with pain, inflammation, cinod and gallstones
8) Confidence 0.59 Published 1993 Journal Clin Investig Section Abstract Doc Link 8312687 Disease Relevance 0.60 Pain Relevance 0.38
Indomethacin tissue levels in the gallbladder mucosa, as assessed by HPLC, were 1.05 +/- 0.4 ng/mg wet weight, a concentration known to inhibit effectively cyclooxygenase activity.
Negative_regulation (inhibit) of cyclooxygenase
9) Confidence 0.59 Published 1993 Journal Clin Investig Section Abstract Doc Link 8312687 Disease Relevance 0.52 Pain Relevance 0.37
These NSAIDs are well-known inhibitors of both the cytoprotective isoform of prostaglandin endoperoxide synthase-1 (PGHS-1) and of the inducible form (PGHS-2).
Negative_regulation (inhibitors) of PGHS-1 associated with cinod
10) Confidence 0.59 Published 1997 Journal J. Invest. Dermatol. Section Abstract Doc Link 9008235 Disease Relevance 0.40 Pain Relevance 0.36
These NSAIDs are well-known inhibitors of both the cytoprotective isoform of prostaglandin endoperoxide synthase-1 (PGHS-1) and of the inducible form (PGHS-2).
Negative_regulation (inhibitors) of prostaglandin endoperoxide synthase-1 associated with cinod
11) Confidence 0.59 Published 1997 Journal J. Invest. Dermatol. Section Abstract Doc Link 9008235 Disease Relevance 0.40 Pain Relevance 0.36
DATA SYNTHESIS: Several controlled pharmacodynamic studies indicate that the sustained inhibition of cyclooxygenase activity by aspirin is blunted in the presence of some NSAIDs.
Negative_regulation (inhibition) of cyclooxygenase
12) Confidence 0.58 Published 2005 Journal Ann Pharmacother Section Body Doc Link 15870140 Disease Relevance 0 Pain Relevance 0
We present here for the first time a method for determining the rate constants associated with slow binding inhibition of prostaglandin H synthase (PGHS).
Negative_regulation (inhibition) of PGHS
13) Confidence 0.58 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631960 Disease Relevance 0 Pain Relevance 0
A major effect of NSAIDs is inhibition of cyclooxygenase, the rate-limiting enzyme for conversion of arachidonic acid to important signal molecules, including prostaglandins, which profoundly affect cellular functions in many tissues.
Negative_regulation (inhibition) of cyclooxygenase associated with cinod
14) Confidence 0.58 Published 1992 Journal J. Cell. Biochem. Suppl. Section Abstract Doc Link 1305681 Disease Relevance 0.54 Pain Relevance 0.54
It remains to be investigated whether mechanisms other than inhibition of cyclooxygenase contribute to the analgesic activity of lysine clonixinate.
Spec (whether) Negative_regulation (inhibition) of cyclooxygenase associated with analgesic
15) Confidence 0.58 Published 1996 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 8866627 Disease Relevance 0.07 Pain Relevance 0.41
Our results indicate that lysine clonixinate is a cyclooxygenase inhibitor of moderate potency.
Negative_regulation (inhibitor) of cyclooxygenase associated with potency
16) Confidence 0.58 Published 1996 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 8866627 Disease Relevance 0.07 Pain Relevance 0.41
Differently, meloxicam, nimesulide and diclofenac were approximately 10- to 20-fold more potent in inhibiting the cyclooxygenase activity of monocyte PGHS-2 than platelet PGHS-1.
Negative_regulation (inhibiting) of cyclooxygenase in monocyte associated with diclofenac
17) Confidence 0.57 Published 1997 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9444611 Disease Relevance 0.36 Pain Relevance 0.40
L-745,337, NS-398 and SC58125 achieved selective inhibition of monocyte PGHS-2 (IC50, PGHS-1/IC50, PGHS-2: < 100) and may provide adequate tools to test the contribution of this novel pathway of arachidonate metabolism to human inflammatory disease and to verify the hypothesis that the common side-effects of NSAIDs are due primarily to their ability to affect the activity of PGHS-1.
Negative_regulation (inhibition) of PGHS in monocyte associated with inflammation, cinod and disease
18) Confidence 0.57 Published 1997 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9444611 Disease Relevance 0.39 Pain Relevance 0.41
At antipyretic and analgesic doses, salicylate has no antiplatelet or anti-inflammatory effects, unlike typical inhibitors of the prostaglandin H synthases (PGHSs).
Negative_regulation (inhibitors) of PGHS associated with inflammation and analgesic
19) Confidence 0.57 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538810 Disease Relevance 0.10 Pain Relevance 0.25
Human cyclooxygenase-1bDeltaG was active but was not inhibited by acetaminophen.
Negative_regulation (inhibited) of cyclooxygenase associated with paracetamol
20) Confidence 0.57 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17045584 Disease Relevance 0 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox