INT239151

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 2.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou1f1) DNA binding (Pou1f1) transcription factor binding (Pou1f1)
cytoplasm (Pou1f1)
Anatomy Link Frequency
embryo 1
thyrotrophs 1
osteoblast 1
somatotrophs 1
lactotrophs 1
Pou1f1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 5 49.20 Quite Low
cva 10 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 25 99.74 Very High Very High Very High
Embryonic Lethality 43 94.36 High High
Aging 111 86.68 High High
Anaemia 70 81.96 Quite High
Female Infertility 3 76.96 Quite High
Congenital Anomalies 20 76.92 Quite High
Sprains And Strains 11 76.40 Quite High
Thyroid Disease 3 75.20 Quite High
Cancer 45 64.28 Quite High
Stress 279 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, wild-type PiT1 mRNA levels are significantly reduced both in PiT1neo/+ and PiT1neo/neo E11.5 embryo (35% and 15% of the wild-type, respectively) (Fig. 1F).
Transcription (levels) of PiT1 in embryo
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0 Pain Relevance 0
Wild-type PiT1 mRNA levels in E12.5 PiT1neo/?
Transcription (levels) of PiT1
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.24 Pain Relevance 0
Real-time RT-PCR analysis of RNA extracted from E12.5 PiT1+/+ and PiT1?
Transcription (extracted) of PiT1
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.28 Pain Relevance 0
PiT1 probes (Table S1) were transcribed with SP6 or T7 promoters with the DIG RNA labeling kit (Roche Applied Science).
Transcription (transcribed) of PiT1
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0 Pain Relevance 0
Pit1 is a transcription factor downstream of Prop1 that directs fetal pituitary cell differentiation into somatotrophs, lactotrophs, and thyrotrophs.
Transcription (transcription) of Pit1 in thyrotrophs
5) Confidence 0.58 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.73 Pain Relevance 0
In osteoblast-like cells, PiT1, but not PiT2, mRNA expression and Na+-Pi cotransport are regulated by various factors such as Pi [10], epinephrine [11], insulin-like growth factor 1 (IGF-1) [12], [13] and bone morphogenic protein 2 (BMP2) [14].
Transcription (expression) of PiT1 in osteoblast associated with osteoporosis
6) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.24 Pain Relevance 0
Pit1 is a transcription factor downstream of Prop1 that directs fetal pituitary cell differentiation into somatotrophs, lactotrophs, and thyrotrophs.
Transcription (transcription) of Pit1 in somatotrophs
7) Confidence 0.20 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.73 Pain Relevance 0
Pit1 is a transcription factor downstream of Prop1 that directs fetal pituitary cell differentiation into somatotrophs, lactotrophs, and thyrotrophs.
Transcription (transcription) of Pit1 in lactotrophs
8) Confidence 0.20 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.73 Pain Relevance 0

General Comments

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