INT239157

Context Info Confidence 0.11 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.89 Pain Relevance 0

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor) endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)

Anatomy Link Frequency primary neurons 2 Mtor (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 3 34.00 Clonidine 7 5.00 Hippocampus 3 5.00 cerebral cortex 2 5.00 Inflammation 2 5.00 agonist 2 5.00 medulla 2 5.00 Central nervous system 1 5.00 withdrawal 1 5.00 ischemia 1 5.00

Disease Link Frequency Relevance Heat Lifespan 24 97.24 Cancer 15 96.60 Stress 93 81.44 Aging 37 81.00 Disease 54 73.12 Cardiovascular Disease 1 67.20 Toxicity 6 50.00 Tremor 11 18.08 Death 12 15.36 Weight Loss 4 14.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further analysis of the effects of rilmenidine on primary neurons confirmed that rilmenidine does not act to upregulate autophagy via inactivation of the mTOR pathway.

Positive_regulation (upregulate) of Negative_regulation (inactivation) of mTOR in primary neurons

1) Confidence 0.11 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.13 Pain Relevance 0

In addition, the reduction in PI3K and mTOR signaling and subsequent attenuation of anabolism may simulate a stressful situation and upregulate general defense and repair systems, which, in the long term, extend lifespan.

Positive_regulation (upregulate) of Negative_regulation (reduction) of mTOR associated with lifespan

2) Confidence 0.05 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.77 Pain Relevance 0

General Comments

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