INT239157

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
primary neurons 2
Mtor (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 3 34.00 Quite Low
Clonidine 7 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 24 97.24 Very High Very High Very High
Cancer 15 96.60 Very High Very High Very High
Stress 93 81.44 Quite High
Aging 37 81.00 Quite High
Disease 54 73.12 Quite High
Cardiovascular Disease 1 67.20 Quite High
Toxicity 6 50.00 Quite Low
Tremor 11 18.08 Low Low
Death 12 15.36 Low Low
Weight Loss 4 14.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further analysis of the effects of rilmenidine on primary neurons confirmed that rilmenidine does not act to upregulate autophagy via inactivation of the mTOR pathway.
Positive_regulation (upregulate) of Negative_regulation (inactivation) of mTOR in primary neurons
1) Confidence 0.11 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.13 Pain Relevance 0
In addition, the reduction in PI3K and mTOR signaling and subsequent attenuation of anabolism may simulate a stressful situation and upregulate general defense and repair systems, which, in the long term, extend lifespan.
Positive_regulation (upregulate) of Negative_regulation (reduction) of mTOR associated with lifespan
2) Confidence 0.05 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.77 Pain Relevance 0

General Comments

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