INT239158

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.26
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aco1) mitochondrion (Aco1) lyase activity (Aco1)
Golgi apparatus (Aco1) endoplasmic reticulum (Aco1) RNA binding (Aco1)
Anatomy Link Frequency
liver 2
neuron 2
Aco1 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 18 58.96 Quite High
Substantia nigra 1 50.96 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 64 93.80 High High
Stress 105 92.40 High High
Targeted Disruption 35 83.12 Quite High
Cancer 15 67.52 Quite High
Adenoma 1 61.20 Quite High
Obesity 2 60.60 Quite High
Body Weight 1 52.60 Quite High
Aging 38 50.00 Quite Low
Drug Induced Neurotoxicity 8 50.00 Quite Low
Disease 13 42.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note, the use of PQ2+ as a toxicant was particularly advantageous in our model because in contrast to neuron-specific toxicants such as MPP+, PQ2+ is capable of inactivating m-aconitase in both mixed neuronal/glial cultures and near pure astrocytic cultures [30].
Negative_regulation (capable) of Positive_regulation (inactivating) of m-aconitase in neuron
1) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 0.58 Pain Relevance 0.05
These transgenics exhibit lower basal levels of liver mitochondrial SOD2 mRNA and protein, lower SOD2 activity levels, reduced lipid oxidation, and increased aconitase activity in mitochondria compared with wild-type mice.
Negative_regulation (exhibit) of Positive_regulation (increased) of aconitase in liver
2) Confidence 0.07 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.68 Pain Relevance 0

General Comments

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