INT239158

Context Info Confidence 0.17 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.26 Pain Relevance 0.05

cytosol (Aco1) mitochondrion (Aco1) lyase activity (Aco1) Golgi apparatus (Aco1) endoplasmic reticulum (Aco1) RNA binding (Aco1)

Anatomy Link Frequency liver 2 neuron 2 Aco1 (Mus musculus)

Pain Link Frequency Relevance Heat midbrain 18 58.96 Substantia nigra 1 50.96 Inflammation 3 5.00 tolerance 3 5.00 ischemia 2 5.00 cerebral cortex 1 5.00 withdrawal 1 5.00 Pain 1 5.00 Paracetamol 1 5.00 addiction 1 5.00

Disease Link Frequency Relevance Heat Death 64 93.80 Stress 105 92.40 Targeted Disruption 35 83.12 Cancer 15 67.52 Adenoma 1 61.20 Obesity 2 60.60 Body Weight 1 52.60 Aging 38 50.00 Drug Induced Neurotoxicity 8 50.00 Disease 13 42.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Of note, the use of PQ2+ as a toxicant was particularly advantageous in our model because in contrast to neuron-specific toxicants such as MPP+, PQ2+ is capable of inactivating m-aconitase in both mixed neuronal/glial cultures and near pure astrocytic cultures [30].

Negative_regulation (capable) of Positive_regulation (inactivating) of m-aconitase in neuron

1) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 0.58 Pain Relevance 0.05

These transgenics exhibit lower basal levels of liver mitochondrial SOD2 mRNA and protein, lower SOD2 activity levels, reduced lipid oxidation, and increased aconitase activity in mitochondria compared with wild-type mice.

Negative_regulation (exhibit) of Positive_regulation (increased) of aconitase in liver

2) Confidence 0.07 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.68 Pain Relevance 0

General Comments

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