INT239181

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gh, Sod1) cytosol (Gh, Sod1) extracellular space (Gh, Sod1)
nucleus (Gh, Sod1) aging (Sod1) peroxisome (Sod1)
Gh (Mus musculus)
Sod1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 22 97.44 Very High Very High Very High
Aging 37 88.48 High High
Stress 93 77.08 Quite High
Toxicity 3 48.48 Quite Low
Death 5 28.48 Quite Low
Targeted Disruption 35 13.12 Low Low
Cancer 15 5.00 Very Low Very Low Very Low
Shock 7 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In strong support of this work are reports indicating that GH overexpression in vivo suppresses catalase and SOD1, increases tissue oxidative damage, and significantly shortens lifespan (Brown-Borg and Rakoczy 2000; Brown-Borg et al. 1999, 2001b, 2002; Hauck and Bartke 2001; Pendergrass et al. 1993; Wolf et al. 1993; Rollo et al. 1996).
Gene_expression (overexpression) of GH Negative_regulation (suppresses) of SOD1 associated with lifespan
1) Confidence 0.24 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.33 Pain Relevance 0

General Comments

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