INT239185

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Clk1, Shc1) cytoplasm (Clk1, Shc1) mitochondrion (Shc1)
aging (Shc1) plasma membrane (Shc1) kinase activity (Clk1)
Clk1 (Mus musculus)
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 70 100.00 Very High Very High Very High
Lifespan 44 89.60 High High
Stress 186 86.00 High High
Aging 74 83.56 Quite High
Cancer 30 5.00 Very Low Very Low Very Low
Shock 14 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-MUPA knockout, p66shc knockout, FIRKO, mClk-1 heterozygote, thioredoxin transgenic, and most recently the Klotho transgenic mouse.
mClk-1 Binding (heterozygote) of p66shc associated with targeted disruption
1) Confidence 0.04 Published 2006 Journal Age (Dordr) Section Abstract Doc Link PMC2464727 Disease Relevance 1.10 Pain Relevance 0
-MUPA knockout, p66shc knockout, FIRKO, mClk-1 heterozygote, thioredoxin transgenic, and most recently the Klotho transgenic mouse.
mClk-1 Binding (heterozygote) of p66shc associated with targeted disruption
2) Confidence 0.04 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 1.32 Pain Relevance 0

General Comments

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