INT239193

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.64
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (foxo) cytoplasm (foxo)
Anatomy Mention Frequency
motor nerve 1
muscle 1
myotubes 1
foxo (Drosophila melanogaster)
Pain Term Frequency Confidence Heat
Glutamate receptor 5 97.52 Very High Very High Very High
Neuronal excitability 25 96.96 Very High Very High Very High
Glutamate 40 96.80 Very High Very High Very High
Neurotransmitter 2 96.60 Very High Very High Very High
Inflammation 4 30.56 Quite Low
agonist 3 21.44 Low Low
hyperexcitability 9 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Stress 93 97.74 Very High Very High Very High
Hyperinsulinism 7 90.08 High High
Epilepsy 8 85.80 High High
Hyperplasia 2 85.52 High High
Neurological Disease 6 85.08 High High
Muscular Atrophy 2 80.16 Quite High
Aging 37 77.96 Quite High
Autism 3 76.56 Quite High
Neurofibromatosis 2 75.68 Quite High
Schizophrenia 4 61.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this mechanism, activation by the excitatory neurotransmitter glutamate of metabotropic glutamate receptors (mGluRs) located at motor nerve terminals decreases excitability by activating PI3 kinase (PI3K), consequently causing the phosphorylation and inhibition of the transcription factor Foxo.
Phosphorylation (phosphorylation) of Foxo in motor nerve associated with glutamate, neurotransmitter and glutamate receptor
1) Confidence 0.60 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2581892 Disease Relevance 0.93 Pain Relevance 0.42
However, when nutrients are scarce, growth factors are deficient, oxidative stress is present or signaling is impaired via mutations in the IGF-1/insulin receptors or their downstream effectors, phosphorylation of FOXO is inhibited, and its nuclear translocation is promoted.
Phosphorylation (phosphorylation) of FOXO associated with stress
2) Confidence 0.08 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.53 Pain Relevance 0
PKB-induced phosphorylation of FOXO transcription factors control ubiquitin ligase expression, resulting in inhibition of the ubiquitin-proteasome protein degradation system in myotubes and mouse muscle (29).
Phosphorylation (phosphorylation) of FOXO in myotubes
3) Confidence 0.05 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0.09 Pain Relevance 0
There is no mechanistic information from work in human muscle showing how insulin might reduce MPB, although there is evidence that insulin-stimulated PKB activity induces phosphorylation of the FOXO family of transcription factors (18, 32), which inhibits their transcriptional activity by localizing them to the cytoplasm.
Phosphorylation (phosphorylation) of FOXO in muscle
4) Confidence 0.03 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox