INT239215

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 6.75
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) extracellular matrix organization (Agt)
Anatomy Link Frequency
fat 1
heart 1
Agt (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 36 99.90 Very High Very High Very High
Serotonin 32 99.80 Very High Very High Very High
antagonist 52 99.60 Very High Very High Very High
Potency 4 98.72 Very High Very High Very High
cytokine 5 97.72 Very High Very High Very High
Onset of action 4 95.08 Very High Very High Very High
fibrosis 30 89.24 High High
5HT 2 88.96 High High
Eae 8 68.88 Quite High
ischemia 7 68.80 Quite High
Disease Link Frequency Relevance Heat
Metabolic Syndrome 13 99.76 Very High Very High Very High
Hypertrophy 21 99.48 Very High Very High Very High
Hypertension 157 99.28 Very High Very High Very High
Ureteral Obstruction 16 98.44 Very High Very High Very High
Obesity 12 98.38 Very High Very High Very High
Cognitive Disorder 124 97.90 Very High Very High Very High
Hypertensive Encephalopathy 4 97.88 Very High Very High Very High
Coronary Heart Disease 30 97.68 Very High Very High Very High
Stroke 8 96.72 Very High Very High Very High
Myocardial Infarction 28 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since both block AngII action via degradation and binding of AngII, respectively, the antihypertensive effect results from a loss of AngII stimulation in pregnant SHRs.
AngII Binding (binding) of
1) Confidence 0.38 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.15 Pain Relevance 0
Our data suggest that AngII degradation in blood is a much more effective approach than blocking AngII receptor binding in treating imminent hypertension as resulting from hypertensive encephalopathy, apoplexy, and acute heart failure, and acute dissection of aorta.

9.

AngII Binding (binding) of in heart associated with hypertensive encephalopathy, stroke, hypertension and myocardial infarction
2) Confidence 0.38 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.72 Pain Relevance 0
The potency of AngIII as a hypertensive agent is approximately 25% that of AngII making AngII the more important ligand; hence, APA has also been called angiotensinase.
AngII Binding (making) of associated with hypertension and potency
3) Confidence 0.30 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.56 Pain Relevance 0.05
The potency of AngIII as a hypertensive agent is approximately 25% that of AngII making AngII the more important ligand; hence, APA has also been called angiotensinase.
AngII Binding (making) of associated with hypertension and potency
4) Confidence 0.30 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.56 Pain Relevance 0.05
Our experiments studied the interaction of angiotensin IV both in vitro and on the behaviour of BKW mice.
angiotensin IV Binding (interaction) of
5) Confidence 0.20 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.20 Pain Relevance 0.08
The salient points of their argument are: the effects of enzyme inhibition and accumulation of endogenous peptides are slow, in the order of hours or days, whilst the onset of action of angiotensin IV in some tissues is within seconds; the concentrations of angiotensin IV required to produce biological, that is, cognitive effects, are well below the concentrations required to inhibit IRAP; and there is dispute as to whether angiotensin IV is a competitive substrate of IRAP or whether it binds allosterically.
angiotensin IV Spec (whether) Binding (binds) of associated with cognitive disorder and onset of action
6) Confidence 0.16 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.18 Pain Relevance 0.16
The endogenous peptide LVV-Hemorphin-7, which is structurally unrelated to angiotensin IV but known to bind to AT4 receptors, inhibits the enzymatic activity of IRAP in vitro, similar to angiotensin IV.
angiotensin IV Binding (bind) of
7) Confidence 0.16 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.08 Pain Relevance 0
To summarise the argument: the AT4 receptor and IRAP have identical binding properties for angiotensin IV, and expression of the cDNA for IRAP gives rise to a protein with the binding characteristics of the AT4 receptor.
angiotensin IV Binding (binding) of
8) Confidence 0.16 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.05 Pain Relevance 0
The interactions between the angiotensin and serotonin systems in cardiac cells could play a major role in the development of cardiac hypertrophy [8].
angiotensin Binding (interactions) of associated with coronary heart disease and serotonin
9) Confidence 0.11 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 1.31 Pain Relevance 0.37
Angiotensin II is formed from angiotensin I by the action of the angiotensin-II converting enzyme (ACE).
angiotensin Binding (action) of
10) Confidence 0.10 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.92 Pain Relevance 0.27
First, we stimulated rVSMCs with angiotensin for different times, immunoprecipitated TRPV4, and subsequently detected ?
angiotensin Binding (rVSMCs) of
11) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
The demonstration that angiotensinogen produced by the adipose tissue may be released in the bloodstream suggests that the high circulating levels of angiotensinogen associated with obesity may be attributable in part to increased fat mass.
angiotensinogen Binding (associated) of in fat associated with obesity and metabolic syndrome
12) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 1.39 Pain Relevance 0.03
agonist and interaction with angiotensin receptor antagonist in the unilateral ureteral obstruction (UUO) model.
angiotensin Binding (interaction) of associated with ureteral obstruction, antagonist and agonist
13) Confidence 0.01 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2799997 Disease Relevance 0.53 Pain Relevance 0.34

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