INT239217

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 47
Total Number 47
Disease Relevance 48.80
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Agtrap) endoplasmic reticulum (Agtrap) plasma membrane (Agtrap)
Anatomy Link Frequency
liver 10
retina 3
brain 2
smooth muscle 1
aorta 1
Agtrap (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 104 99.32 Very High Very High Very High
Hippocampus 29 99.12 Very High Very High Very High
Cold hyperalgesia 2 98.84 Very High Very High Very High
antagonist 140 97.84 Very High Very High Very High
Abstinence syndrome 6 97.48 Very High Very High Very High
allodynia 80 95.40 Very High Very High Very High
agonist 155 94.64 High High
Neurotransmitter 38 94.08 High High
fortral 52 91.64 High High
Trk A 22 86.32 High High
Disease Link Frequency Relevance Heat
Metastasis 1280 99.96 Very High Very High Very High
Hyperplasia 60 99.92 Very High Very High Very High
Colon Cancer 1312 99.84 Very High Very High Very High
Diabetes Mellitus 1183 99.82 Very High Very High Very High
Cancer 1211 99.52 Very High Very High Very High
Hypertrophic Cardiomyopathy 336 99.42 Very High Very High Very High
Lung Cancer 48 99.28 Very High Very High Very High
Coronary Heart Disease 145 98.64 Very High Very High Very High
Hyperalgesia 16 98.64 Very High Very High Very High
Increased Venous Pressure Under Development 92 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both, AT1R and miR-155, are abundantly expressed in the same cell types (e.g.
Gene_expression (expressed) of AT1R
1) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.34 Pain Relevance 0
The regulation of AT1R by miR-155 and the differential binding of this miRNA to mRNAs with 1166 A or C provided a mechanism by which this SNP could lead to a heterogeneous AT1R expression and cardiovascular risk.
Gene_expression (expression) of AT1R
2) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.32 Pain Relevance 0
Although a direct effect of this SNP on AT1R expression could explain its association to cardiac hypertrophy and other cardiovascular disorders, we cannot exclude that this association was a consequence to its linkage disequilibrium with other AT1R variants.
Gene_expression (expression) of AT1R associated with coronary heart disease
3) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.33 Pain Relevance 0
This could represent a predisposition to develop HCM among individuals with this AT1R allele, although the OR was relatively low (1.56) in this group of patients and 41% of the 205 patients without a myofilament mutation were non-carriers of this allele.
Gene_expression (allele) of AT1R associated with hypertrophic cardiomyopathy
4) Confidence 0.67 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.66 Pain Relevance 0.03
Both, AT1R and miR-155, are abundantly expressed in the same cell types (e.g.
Gene_expression (Both) of AT1R
5) Confidence 0.67 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.34 Pain Relevance 0
The genotyping of the 5-HT2A, 5-HTT, AGT, ACE, and AT1R polymorphisms showed a significantly higher frequency of carriers of the AT1R C allele (AC+CC genotypes) in the HCM patients without sarcomeric gene mutations compared to the healthy controls (p = 0.015; OR = 1.56; 95% CI = 1.09-2.23) (Table 2).
Gene_expression (genotyping) of AT1R associated with hypertrophic cardiomyopathy
6) Confidence 0.67 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.81 Pain Relevance 0
We examined the difference for the main characteristics between the 5-HT2A, 5-HTT, AGT, ACE, and AT1R genotypes in the 205 patients without sarcomeric mutations.
Gene_expression (genotypes) of AT1R
7) Confidence 0.67 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.56 Pain Relevance 0
Reasonably, the present ERG findings, in concert with our recent data on AT1R expression in the inner retinal neurons (14), the cellular origins of OPs, suggest that the functional recovery of the diabetic inner retina was attributable in part to the direct effect of AT1R blockade on the inner retinal neurons.
Gene_expression (expression) of AT1R in neurons associated with diabetes mellitus
8) Confidence 0.64 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.85 Pain Relevance 0
Diabetes-induced retinal production of angiotensin II and AT1R led to ERK activation.
Gene_expression (production) of AT1R associated with diabetes mellitus
9) Confidence 0.64 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.43 Pain Relevance 0
In the diabetic retina, the production of angiotensin II and AT1R was upregulated, leading to ERK activation in the downstream of AT1R signaling (Fig. 1).
Gene_expression (production) of AT1R in retina associated with diabetes mellitus
10) Confidence 0.64 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.91 Pain Relevance 0
Recently, we revealed the coexpression of AT1R and the synaptic protein synaptophysin in the inner retinal neurons (14), consistent with several previous reports showing synaptic expression of AT1R in the brain (15–18).
Gene_expression (coexpression) of AT1R in brain
11) Confidence 0.64 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.82 Pain Relevance 0.03
Recently, we revealed the coexpression of AT1R and the synaptic protein synaptophysin in the inner retinal neurons (14), consistent with several previous reports showing synaptic expression of AT1R in the brain (15–18).
Gene_expression (expression) of AT1R in brain
12) Confidence 0.64 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.70 Pain Relevance 0
A resequencing of the AT1R in patients carrying the C-allele should be necessary to identify other variants that could be linked to the risk for cardiac hypertrophy.
Gene_expression (resequencing) of AT1R associated with coronary heart disease
13) Confidence 0.59 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.47 Pain Relevance 0.06
The pro-angiogenic effects of ANG II are mediated by the ANG II type 1 receptor (AT1R), which is overexpressed in several human cancers [7-19].
Gene_expression (overexpressed) of AT1R associated with cancer
14) Confidence 0.55 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.21 Pain Relevance 0
ACE, AT1R, MasR, and angiotensinogen were differentially expressed in control CRC liver metastases compared to the naïve (non-tumor bearing) and the tumor-bearing liver.
Gene_expression (expressed) of AT1R in liver associated with cancer, colon cancer and metastasis
15) Confidence 0.55 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.20 Pain Relevance 0
Key components of the RAS, namely angiotensinogen, ACE, ACE2, AT1R, AT2R, and the MasR were expressed in the sham liver, tumor-induced liver, and in CRC liver metastases (tumors) at all stages examined.
Gene_expression (expressed) of AT1R in liver associated with cancer, colon cancer and metastasis
16) Confidence 0.55 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.00 Pain Relevance 0
The retinal levels of synaptophysin protein, reduced by inducing diabetes, were significantly (P < 0.01) reversed in 4-week diabetic mice by AT1R blockade with telmisartan or valsartan (Fig. 3A and B).
Gene_expression (blockade) of AT1R associated with diabetes mellitus
17) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.62 Pain Relevance 0.05
The protein, but not mRNA, reduction of synaptophysin in neuronal cells was shown to depend on the UPS, which was enhanced via AT1R signaling (Fig. 4).
Gene_expression (signaling) of AT1R in neuronal
18) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.82 Pain Relevance 0
Mice were intraperitoneally injected with the AT1R blocker (ARB) telmisartan or valsartan (U.S.
Gene_expression (blocker) of AT1R
19) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.74 Pain Relevance 0.03
In contrast, AT1R blockade did not alter normal ERG waves in nondiabetic mice (data not shown).


Gene_expression (blockade) of AT1R
20) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.62 Pain Relevance 0.03

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