INT239222

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.54
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Agtrap) endoplasmic reticulum (Agtrap) plasma membrane (Agtrap)
Anatomy Link Frequency
retina 4
aorta 4
hippocampus 2
Agtrap (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 16 99.68 Very High Very High Very High
antagonist 69 97.84 Very High Very High Very High
Abstinence syndrome 3 97.48 Very High Very High Very High
agonist 74 93.28 High High
Inflammation 70 85.44 High High
midbrain 1 76.00 Quite High
addiction 3 74.72 Quite High
withdrawal 1 71.52 Quite High
cocaine 61 61.48 Quite High
Eae 7 51.88 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 324 99.98 Very High Very High Very High
Cancer 80 99.28 Very High Very High Very High
Hyperplasia 9 99.00 Very High Very High Very High
Increased Venous Pressure Under Development 78 98.16 Very High Very High Very High
Syndrome 3 97.48 Very High Very High Very High
Coronary Heart Disease 30 97.40 Very High Very High Very High
Appetite Loss 1 95.68 Very High Very High Very High
Myocardial Infarction 17 93.76 High High
Hypertension 61 93.04 High High
Adhesions 32 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the diabetic retina, the production of angiotensin II and AT1R was upregulated, leading to ERK activation in the downstream of AT1R signaling (Fig. 1).
Positive_regulation (upregulated) of Gene_expression (production) of AT1R in retina associated with diabetes mellitus
1) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.91 Pain Relevance 0
The pro-angiogenic effects of ANG II are mediated by the ANG II type 1 receptor (AT1R), which is overexpressed in several human cancers [7-19].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of AT1R associated with cancer
2) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.21 Pain Relevance 0
The regulation of AT1R by miR-155 and the differential binding of this miRNA to mRNAs with 1166 A or C provided a mechanism by which this SNP could lead to a heterogeneous AT1R expression and cardiovascular risk.
Positive_regulation (lead) of Gene_expression (expression) of AT1R
3) Confidence 0.47 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.33 Pain Relevance 0
A resequencing of the AT1R in patients carrying the C-allele should be necessary to identify other variants that could be linked to the risk for cardiac hypertrophy.
Positive_regulation (necessary) of Gene_expression (resequencing) of AT1R associated with coronary heart disease
4) Confidence 0.44 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.49 Pain Relevance 0.07
Diabetes-induced retinal production of angiotensin II and AT1R led to ERK activation.
Positive_regulation (led) of Gene_expression (production) of AT1R associated with diabetes mellitus
5) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.43 Pain Relevance 0
Diabetes-induced retinal production of angiotensin II and AT1R led to ERK activation.
Positive_regulation (induced) of Gene_expression (production) of AT1R associated with diabetes mellitus
6) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.43 Pain Relevance 0
In the diabetic retina, the production of angiotensin II and AT1R was upregulated, leading to ERK activation in the downstream of AT1R signaling (Fig. 1).
Positive_regulation (leading) of Gene_expression (production) of AT1R in retina associated with diabetes mellitus
7) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.91 Pain Relevance 0
Angiotensin-converting enzyme (ACE) inhibitors, prevent the conversion of angiotensin I to angiotensin II by ACE.
Positive_regulation (conversion) of Gene_expression (conversion) of angiotensin I
8) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.37 Pain Relevance 0.13
Irbesartan but not amlodipine treatment attenuated the development of atherosclerosis, collagen content, cellular proliferation, and macrophage infiltration as well as diabetes-induced AT-1 receptor, PDGF-B, MCP-1, and VCAM-1 overexpression in the aorta, despite similar blood pressure reductions by both treatments (Candido et al 2004).
Positive_regulation (overexpression) of Gene_expression (overexpression) of AT-1 receptor in aorta associated with diabetes mellitus, increased venous pressure under development and hyperplasia
9) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.98 Pain Relevance 0.04
Irbesartan but not amlodipine treatment attenuated the development of atherosclerosis, collagen content, cellular proliferation, and macrophage infiltration as well as diabetes-induced AT-1 receptor, PDGF-B, MCP-1, and VCAM-1 overexpression in the aorta, despite similar blood pressure reductions by both treatments (Candido et al 2004).
Positive_regulation (induced) of Gene_expression (overexpression) of AT-1 receptor in aorta associated with diabetes mellitus, increased venous pressure under development and hyperplasia
10) Confidence 0.06 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.98 Pain Relevance 0.04
1 receptor expression was increased in the hippocampus of mice after chronic ethanol consumption.
Positive_regulation (increased) of Gene_expression (expression) of 1 receptor in hippocampus associated with hippocampus
11) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701284 Disease Relevance 0.49 Pain Relevance 0.55

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox