INT239226

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.59
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ednra) extracellular space (Edn1) extracellular region (Edn1)
plasma membrane (Ednra) signal transducer activity (Ednra) cell-cell signaling (Edn1)
Anatomy Link Frequency
smooth muscle cells 1
Edn1 (Mus musculus)
Ednra (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 27 99.96 Very High Very High Very High
bradykinin 10 68.68 Quite High
metalloproteinase 66 67.72 Quite High
Central nervous system 3 62.72 Quite High
chemokine 2 44.00 Quite Low
Inflammation 53 5.00 Very Low Very Low Very Low
cytokine 20 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 40 98.52 Very High Very High Very High
Pre-eclampsia 3 98.28 Very High Very High Very High
Cancer 7 91.08 High High
Hypertension 28 90.68 High High
Pathologic Processes 3 89.20 High High
Premature Birth 120 70.16 Quite High
Infection 105 69.56 Quite High
Pre-term Labor 39 56.08 Quite High
Adhesions 12 45.08 Quite Low
Atherosclerotic Plaque 1 25.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the ETA receptor has such a great affinity for ET-1, the possible therapeutic benefit of selective ETA receptor antagonists in preeclamptic women needs to be further explored.
ET-1 Binding (affinity) of ETA receptor associated with antagonist
1) Confidence 0.06 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.47 Pain Relevance 0.08
While the ETA receptor has a much greater affinity for ET-1 as compared to ET-2 and ET-3, the ETB receptor binds all three members with equal affinity [58].
ET-1 Binding (affinity) of ETA receptor
2) Confidence 0.05 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.33 Pain Relevance 0.06
Because the ETA receptor has such a great affinity for ET-1, the possible therapeutic benefit of selective ETA receptor antagonists in preeclamptic women needs to be further explored.
ET-1 Binding (affinity) of ETA receptor associated with antagonist
3) Confidence 0.05 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.42 Pain Relevance 0.08
The interactions of ET-1 with its receptors, ETA and ETB, are responsible either for vasoconstriction, or induction of vascular smooth muscle cells proliferation (Arai et al 1990; Sakurai et al 1990).
ET-1 Binding (interactions) of ETA in smooth muscle cells associated with increased venous pressure under development
4) Confidence 0.00 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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