INT239247

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.68
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (APOA5) transport (APOA5) extracellular space (APOA5)
small molecule metabolic process (APOA5) extracellular region (APOA5) enzyme binding (APOA5)
Anatomy Link Frequency
plasma 2
smooth muscle 1
left atrium 1
APOA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 16 83.36 Quite High
Bile 9 82.92 Quite High
anesthesia 4 79.44 Quite High
Dismenorea 6 76.68 Quite High
analgesia 1 74.40 Quite High
Mechanotransduction 12 53.12 Quite High
imagery 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 141 99.96 Very High Very High Very High
Disorder Of Lipid Metabolism 101 94.76 High High
Injury 2 93.60 High High
Increased Venous Pressure Under Development 9 93.08 High High
Mitral Valve Insufficiency 38 91.76 High High
Familial Combined Hyperlipidemia 6 90.72 High High
Polyhydramnios 9 87.36 High High
Hyperlipidemia 4 85.12 High High
Pre-term Labor 18 83.80 Quite High
Dysmenorrhea 6 76.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A complex pattern of gene expression has been demonstrated through in vivo studies, wherein the Apo CIII enhancer acts as a common regulatory element for the APOA1-C3-A4 genes but not for the APOA5 gene [5].
Positive_regulation (acts) of APOA5
1) Confidence 0.37 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.68 Pain Relevance 0
increases APOA5 [54–56] and decreases APOC3 [57] transcription, resulting in a plasma TAG lowering effect, thereby, together with increased HDL concentrations, reducing the risk for atherosclerosis in humans [58].
Positive_regulation (increases) of APOA5 in plasma associated with increased venous pressure under development and disorder of lipid metabolism
2) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.83 Pain Relevance 0.14
results in increased lipolysis and plasma clearance of atherogenic triglyceride-rich lipoproteins via the activation of lipoprotein lipase and ApoAV and reduced production of the lipoprotein lipase inhibitor ApoCIII (Haubenwallner et al 1995; Staels et al 1995a; Stael et al 1998; Chapman et al 2006).
Positive_regulation (activation) of ApoAV in plasma
3) Confidence 0.20 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 0.13 Pain Relevance 0
The Edwards-Sapien valve was first implanted via the antegrade transseptal approach to the left atrium and passage through the mitral valve to reach the AV [19].
Positive_regulation (reach) of AV in left atrium
4) Confidence 0.01 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2926577 Disease Relevance 0.39 Pain Relevance 0.15
In summary, as illustrated in Fig. 8, the immunoprecipitation experiments demonstrated interactions between these phosphorylated proteins within focal adhesion complexes and point to a direct mechanistic link between focal adhesions, SmAV and ERK activation.


Positive_regulation (activation) of SmAV associated with adhesions
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.54 Pain Relevance 0
A newly produced SmAV-specific antibody demonstrates gestation-specific increases in SmAV protein levels and stretch-specific increases in SmAV association with focal adhesion proteins.
Positive_regulation (increases) of SmAV associated with adhesions
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759504 Disease Relevance 0.52 Pain Relevance 0
In the present study we report that expression levels of a newly identified smooth muscle protein, SmAV, increase significantly during pregnancy.
Positive_regulation (increase) of SmAV in smooth muscle
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.59 Pain Relevance 0.21

General Comments

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