INT239279

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.42
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abca1) Golgi apparatus (Abca1) ATPase activity (Abca1)
plasma membrane (Abca1) intracellular (Abca1)
Anatomy Link Frequency
macrophage 2
Abca1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 47 99.60 Very High Very High Very High
Bioavailability 2 92.40 High High
cINOD 14 22.80 Low Low
COX-2 inhibitor 4 13.52 Low Low
Inflammation 15 5.00 Very Low Very Low Very Low
alcohol 11 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 72 99.84 Very High Very High Very High
Metabolic Syndrome 1 97.20 Very High Very High Very High
Insulin Resistance 2 96.12 Very High Very High Very High
Colon Cancer 2 88.24 High High
Atherosclerosis 49 86.16 High High
Disorder Of Lipid Metabolism 288 74.28 Quite High
Targeted Disruption 10 56.40 Quite High
Atherosclerotic Plaque 3 41.12 Quite Low
Cancer 30 15.64 Low Low
Hypolipidemia 2 11.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, indomethacin down-regulates the expression of some of the ABC transporters, which are up regulated in CRC [38,41].
Regulation (regulated) of Gene_expression (expression) of ABC associated with colorectal cancer
1) Confidence 0.44 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.74 Pain Relevance 0.09
Interestingly, indomethacin down-regulates the expression of some of the ABC transporters, which are up regulated in CRC [38,41].
Regulation (regulates) of Gene_expression (expression) of ABC associated with colorectal cancer
2) Confidence 0.44 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.74 Pain Relevance 0.08
agonists have been shown to upregulate LXR and ABCA1 expression and promote macrophage cholesterol efflux (Schmitz et al 2002; Chawla et al 2001).
Regulation (upregulate) of Gene_expression (expression) of ABCA1 in macrophage associated with agonist
3) Confidence 0.27 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.93 Pain Relevance 0.10

General Comments

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