INT239289

Context Info Confidence 0.31 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.27 Pain Relevance 0.50

endosome (Abcg1) transport (Abcg1) Golgi apparatus (Abcg1) ATPase activity (Abcg1) plasma membrane (Abcg1) intracellular (Abcg1)

Abcg1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 49 94.88 Inflammation 37 91.60 Bile 48 61.60 cytokine 2 48.48 alcohol 12 5.00 antagonist 11 5.00 Angina 6 5.00 Crohn's disease 6 5.00 aspirin 5 5.00 antidepressant 3 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 592 93.20 INFLAMMATION 31 91.60 Atherosclerosis 105 89.60 Insulin Resistance 5 81.52 Metabolic Syndrome 13 79.36 Targeted Disruption 31 75.68 Neurodegenerative Disease 1 68.32 Van Bogaert's Disease 1 67.16 Dyslipidemia / Combined Dyslipidemia 11 62.72 Congenital Anomalies 6 61.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When activated by oxysterols from FC this heterodimer stimulates ABCA1 and ABCG1 gene expression, thereby enhancing cholesterol efflux (Vaughan and Oram 2005; Venkateswaran et al 2000).

Gene_expression (expression) of ABCG1 gene

1) Confidence 0.31 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.11 Pain Relevance 0.07

Moreover, the authors showed that SXR can also induce ABCA1 and ABCG1 expression and promote cholesterol efflux in the same cells.

Gene_expression (expression) of ABCG1

2) Confidence 0.30 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.21 Pain Relevance 0.06

and increase expression of ABCA-1 and ABCG-1 but they are not therapeutically usable as such.

Gene_expression (expression) of ABCG-1

3) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.89 Pain Relevance 0.37

General Comments

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