INT239289

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.27
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Abcg1) transport (Abcg1) Golgi apparatus (Abcg1)
ATPase activity (Abcg1) plasma membrane (Abcg1) intracellular (Abcg1)
Abcg1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 49 94.88 High High
Inflammation 37 91.60 High High
Bile 48 61.60 Quite High
cytokine 2 48.48 Quite Low
alcohol 12 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 592 93.20 High High
INFLAMMATION 31 91.60 High High
Atherosclerosis 105 89.60 High High
Insulin Resistance 5 81.52 Quite High
Metabolic Syndrome 13 79.36 Quite High
Targeted Disruption 31 75.68 Quite High
Neurodegenerative Disease 1 68.32 Quite High
Van Bogaert's Disease 1 67.16 Quite High
Dyslipidemia /

Combined Dyslipidemia

11 62.72 Quite High
Congenital Anomalies 6 61.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When activated by oxysterols from FC this heterodimer stimulates ABCA1 and ABCG1 gene expression, thereby enhancing cholesterol efflux (Vaughan and Oram 2005; Venkateswaran et al 2000).
Gene_expression (expression) of ABCG1 gene
1) Confidence 0.31 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.11 Pain Relevance 0.07
Moreover, the authors showed that SXR can also induce ABCA1 and ABCG1 expression and promote cholesterol efflux in the same cells.
Gene_expression (expression) of ABCG1
2) Confidence 0.30 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.21 Pain Relevance 0.06
and increase expression of ABCA-1 and ABCG-1 but they are not therapeutically usable as such.
Gene_expression (expression) of ABCG-1
3) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.89 Pain Relevance 0.37

General Comments

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