INT239295

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.18
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abca1) Golgi apparatus (Abca1) ATPase activity (Abca1)
plasma membrane (Abca1) intracellular (Abca1)
Anatomy Link Frequency
plaque 1
Abca1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 37 94.56 High High
Inflammation 40 78.24 Quite High
Inflammatory mediators 1 75.04 Quite High
chemokine 4 43.36 Quite Low
ischemia 11 16.72 Low Low
alcohol 22 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 576 99.50 Very High Very High Very High
Atherosclerosis 117 91.36 High High
Diabetes Mellitus 20 90.04 High High
Hypertension 7 89.76 High High
Congenital Anomalies 3 87.52 High High
INFLAMMATION 45 78.24 Quite High
Vasculitis 3 77.60 Quite High
Disease 15 73.44 Quite High
Hyperlipidemia 4 56.04 Quite High
Acute Coronary Syndrome 8 54.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HDL levels and subsequently increase ABCA1-mediated cholesterol efflux from peripheral cells without exerting a significant effect on LDL-C metabolism Animal studies evaluating delipidation therapy followed by intravascular ultrasound assessment of vascular plaque progression or regression are ongoing (Shah 2007).


Positive_regulation (increase) of ABCA1 in plaque associated with atherosclerosis and disorder of lipid metabolism
1) Confidence 0.30 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.94 Pain Relevance 0.11
mediate activation of the LXR/RXR heterodimer, which in turn regulates cholesterol efflux via ABCA1 and ABCG1 activation (Schmitz et al 2002).
Positive_regulation (activation) of ABCA1
2) Confidence 0.28 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.73 Pain Relevance 0.17
and upregulation of ABCA1 appear to induce lipid efflux.
Positive_regulation (upregulation) of ABCA1
3) Confidence 0.26 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 0.52 Pain Relevance 0.04

General Comments

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