INT239296

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.83
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abca1) Golgi apparatus (Abca1) ATPase activity (Abca1)
plasma membrane (Abca1) intracellular (Abca1)
Anatomy Link Frequency
macrophages 1
Abca1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 88.72 High High
agonist 55 5.00 Very Low Very Low Very Low
Inflammation 29 5.00 Very Low Very Low Very Low
alcohol 23 5.00 Very Low Very Low Very Low
Bile 13 5.00 Very Low Very Low Very Low
Angina 9 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 876 98.24 Very High Very High Very High
Atherosclerotic Plaque 7 96.28 Very High Very High Very High
Hypolipidemia 7 90.48 High High
Targeted Disruption 24 85.84 High High
Atherosclerosis 154 75.52 Quite High
Coronary Heart Disease 136 72.20 Quite High
Hypoalphalipoproteinemias 16 66.72 Quite High
Myocardial Infarction 60 5.00 Very Low Very Low Very Low
Cardiovascular Disease 29 5.00 Very Low Very Low Very Low
INFLAMMATION 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heterozygous individuals with a partial reduction in functional ABCA1 have a corresponding 50% decrease in serum HDL-C levels (Marcil et al 1999).
Negative_regulation (reduction) of ABCA1 associated with disorder of lipid metabolism
1) Confidence 0.26 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.30 Pain Relevance 0
In this model, loss of ABCA1 correlated with increased accumulation of lipid-laden macrophages, an integral component of atherosclerotic plaque (McNeish et al 2000).
Negative_regulation (loss) of ABCA1 in macrophages associated with atherosclerotic plaque
2) Confidence 0.23 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.53 Pain Relevance 0
When ABCA-1 is absent or dysfunctional, the apo A-1 gets catabolized too quickly leading to lower levels of apo A-1, and thus lower levels of HDL.
Negative_regulation (absent) of ABCA-1 associated with disorder of lipid metabolism
3) Confidence 0.10 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.00 Pain Relevance 0.04

General Comments

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