INT239302

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 9.10
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abca1) Golgi apparatus (Abca1) ATPase activity (Abca1)
plasma membrane (Abca1) intracellular (Abca1)
Anatomy Link Frequency
macrophages 8
Abca1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 144 99.98 Very High Very High Very High
Inflammation 88 97.52 Very High Very High Very High
Multiple sclerosis 124 71.36 Quite High
cannabis 2 69.76 Quite High
Delta-9-tetrahydrocannabinol 2 66.24 Quite High
Potency 6 61.04 Quite High
rheumatoid arthritis 8 47.24 Quite Low
Neuropathic pain 2 43.20 Quite Low
antagonist 8 41.20 Quite Low
corticosteroid 2 38.40 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 68 99.88 Very High Very High Very High
Disorder Of Lipid Metabolism 2336 98.88 Very High Very High Very High
Atherosclerotic Plaque 20 98.60 Very High Very High Very High
Atherosclerosis 406 97.76 Very High Very High Very High
INFLAMMATION 82 97.52 Very High Very High Very High
Vasculitis 6 96.88 Very High Very High Very High
Increased Venous Pressure Under Development 50 95.32 Very High Very High Very High
Diabetes Mellitus 42 87.76 High High
Coronary Heart Disease 338 82.84 Quite High
Insulin Resistance 16 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
leading to increased expression of ABCA1 and CD36 in macrophages [28, 29].
Positive_regulation (leading) of Gene_expression (expression) of ABCA1 in macrophages
1) Confidence 0.32 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.51 Pain Relevance 0.16
leading to increased expression of ABCA1 and CD36 in macrophages [28, 29].
Positive_regulation (increased) of Gene_expression (expression) of ABCA1 in macrophages
2) Confidence 0.32 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.51 Pain Relevance 0.16
and by enhancing expression of Apo AI and AII, LL, and ABCA1, which collectively enhance RCT (Tilly-Kiesi et al 1992).
Positive_regulation (enhancing) of Gene_expression (expression) of ABCA1
3) Confidence 0.30 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.16 Pain Relevance 0.03
Finally, crossing transgenic mice overexpressing ABCA1 with athero-susceptible transgenic mice, such as LDL receptor (LDLr) or Apolipoprotein E knockout (KO) models, reduced atheromatous progression (Joyce et al 2003).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ABCA1 associated with targeted disruption and disorder of lipid metabolism
4) Confidence 0.28 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.57 Pain Relevance 0
When activated by oxysterols from FC this heterodimer stimulates ABCA1 and ABCG1 gene expression, thereby enhancing cholesterol efflux (Vaughan and Oram 2005; Venkateswaran et al 2000).
Positive_regulation (stimulates) of Gene_expression (expression) of ABCA1
5) Confidence 0.28 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.12 Pain Relevance 0.07
Conversely, overexpression of ABCA1 in transgenic mice is associated with increased TC, HDL-C levels, and Apo AI with enhanced cholesterol efflux and reduced levels of atherogenesis (Brewer et al 2004).
Positive_regulation (overexpression) of Gene_expression (overexpression) of ABCA1 associated with targeted disruption, atherosclerosis and disorder of lipid metabolism
6) Confidence 0.28 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.56 Pain Relevance 0
Non-selective LXR agonists increase ABCA1 synthesis with a gradual increase in HDL-C serum levels (Lund et al 2006).
Positive_regulation (increase) of Gene_expression (synthesis) of ABCA1 associated with agonist and disorder of lipid metabolism
7) Confidence 0.28 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.70 Pain Relevance 0.29
agonists enhance gene expression of SR BI, Apo AI, Apo AII, LPL, and ABCA1 (Toth 2005).
Positive_regulation (enhance) of Gene_expression (expression) of ABCA1 associated with agonist
8) Confidence 0.28 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.63 Pain Relevance 0.26
Cordaptive, by reducing prostaglandin D2 production, thus, may potentially cause an undesirable side effect of decreasing the ability of prostaglandin D2 to stimulate expression of ABCA-1 on the surface of macrophages.


Positive_regulation (stimulate) of Gene_expression (expression) of ABCA-1 in macrophages
9) Confidence 0.16 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.59 Pain Relevance 0.04
agonist that promotes expression of ABCA-1 and increases transfer of cholesterol from macrophages to HDL.
Positive_regulation (promotes) of Gene_expression (expression) of ABCA-1 in macrophages associated with agonist and disorder of lipid metabolism
10) Confidence 0.16 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.75 Pain Relevance 0.05

General Comments

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