INT23932

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.22
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.26
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (ST8SIA2) Golgi apparatus (ST8SIA2) carbohydrate metabolic process (ST8SIA2)
Anatomy Link Frequency
neuronal 1
external 1
ST8SIA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 319 100.00 Very High Very High Very High
addiction 77 99.92 Very High Very High Very High
sodium channel 10 75.00 Quite High
Nav1.6 1 6.20 Low Low
local anesthetic 19 5.00 Very Low Very Low Very Low
Action potential 9 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Nav1.1 5 5.00 Very Low Very Low Very Low
conotoxin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fatigue 4 100.00 Very High Very High Very High
Sprains And Strains 44 99.44 Very High Very High Very High
Hemolytic Uremic Syndrome 8 91.12 High High
Disease 41 89.76 High High
Diarrhoea 39 55.20 Quite High
Infection 25 52.72 Quite High
Renal Failure 1 27.76 Quite Low
Colitis 6 14.84 Low Low
Gastroenteritis 22 5.00 Very Low Very Low Very Low
Heart Arrhythmia 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STX loss of energy of interaction with mutation of Asp-1532 was ?
Negative_regulation (loss) of STX associated with fatigue
1) Confidence 0.22 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0.10 Pain Relevance 0.69
Modifications of gating by lipophilic toxins confer a selective voltage-dependence on STX and TTX inhibition of open channels that is not observed in drug-free channels.
Negative_regulation (inhibition) of STX associated with addiction
2) Confidence 0.18 Published 1987 Journal Annu. Rev. Neurosci. Section Abstract Doc Link 2436544 Disease Relevance 0 Pain Relevance 0.18
If mutated to the neuronal-specific amino acid phenylalanine channels acquire a high sensitivity for STX block, similar to wild-type neuronal channels.
Negative_regulation (block) of STX in neuronal
3) Confidence 0.05 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866490 Disease Relevance 0 Pain Relevance 0.17
Hence, the amino acid at position 374 in rNaV1.5 and in the analogous position in rNaV1.2 determines both isoform specific STX block and isoform specific gating properties.
Spec (determines) Negative_regulation (block) of STX
4) Confidence 0.04 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866490 Disease Relevance 0 Pain Relevance 0.15
The author proposed that divalent or trivalent cations bind to a deep site in the channel thereby reducing TTX or STX binding to an external receptor.
Negative_regulation (reducing) of STX in external associated with tetrodotoxin
5) Confidence 0.04 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866490 Disease Relevance 0 Pain Relevance 0.54
This

probiotic strain was shown to be capable of neutralizing Stx in vitro.

Negative_regulation (neutralizing) of Stx associated with sprains and strains
6) Confidence 0.03 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648624 Disease Relevance 1.16 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox