INT239320

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmgcr) nucleus (Eef1a2) embryo development (Hmgcr)
translation (Eef1a2) GTPase activity (Eef1a2) cytoplasm (Eef1a2)
Eef1a2 (Mus musculus)
Hmgcr (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 1 72.40 Quite High
agonist 15 5.00 Very Low Very Low Very Low
alcohol 11 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 49 97.88 Very High Very High Very High
Disorder Of Lipid Metabolism 288 95.48 Very High Very High Very High
Sudden Death 1 85.28 High High
Myocardial Infarction 19 84.64 Quite High
Infarction 2 79.76 Quite High
Disease 5 53.28 Quite High
Coronary Heart Disease 33 33.36 Quite Low
Insulin Resistance 2 17.72 Low Low
Coronary Artery Disease 6 12.56 Low Low
Cardiovascular Disease 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Statins inhibit HMG-CoA reductase, the rate-limiting step in cholesterol biosynthesis, resulting in increased LDLr density with decreases in LDL, IDL, and VLDL particle synthesis (Farnier 1998; Segrest et al 2000).
Statins Negative_regulation (inhibit) of HMG-CoA reductase associated with disorder of lipid metabolism
1) Confidence 0.06 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.89 Pain Relevance 0.04

General Comments

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