INT239337

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.11
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abca1) Golgi apparatus (Abca1) ATPase activity (Abca1)
plasma membrane (Abca1) intracellular (Abca1)
Abca1 (Mus musculus)
RCT (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 45 92.76 High High
Inflammation 27 74.00 Quite High
Potency 3 63.60 Quite High
ischemia 6 33.80 Quite Low
alcohol 33 5.00 Very Low Very Low Very Low
Bile 12 5.00 Very Low Very Low Very Low
Angina 9 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Nicotine 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 864 100.00 Very High Very High Very High
Atherosclerosis 147 86.16 High High
Targeted Disruption 30 84.60 Quite High
Coronary Heart Disease 99 80.92 Quite High
INFLAMMATION 24 74.00 Quite High
Atherosclerotic Plaque 9 69.32 Quite High
Insulin Resistance 6 65.28 Quite High
Coronary Artery Disease 18 60.12 Quite High
Metabolic Syndrome 3 57.04 Quite High
Infarction 6 49.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and by enhancing expression of Apo AI and AII, LL, and ABCA1, which collectively enhance RCT (Tilly-Kiesi et al 1992).
ABCA1 Positive_regulation (enhance) of RCT
1) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.14 Pain Relevance 0.03
Taken together, these data suggest that both ABCA1 and ABCG1 are potential therapeutic targets to raise HDL-C and promote RCT.
ABCA1 Positive_regulation (promote) of RCT associated with disorder of lipid metabolism
2) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.30 Pain Relevance 0.03
Hydroxylated cholesterol stimulates LXR-mediated transcription of ABCA1, which subsequently enhances RCT from peripheral tissues (Lund et al 2006).
ABCA1 Positive_regulation (enhances) of RCT
3) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.67 Pain Relevance 0.19

General Comments

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