INT239341

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.78
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abca1) Golgi apparatus (Abca1) ATPase activity (Abca1)
plasma membrane (Abca1) intracellular (Abca1)
Anatomy Link Frequency
liver 1
body 1
Abca1 (Mus musculus)
Hdl1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 45 5.00 Very Low Very Low Very Low
alcohol 33 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
Bile 12 5.00 Very Low Very Low Very Low
Angina 9 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Nicotine 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 864 100.00 Very High Very High Very High
Targeted Disruption 30 100.00 Very High Very High Very High
Atherosclerotic Plaque 9 97.88 Very High Very High Very High
Atherosclerosis 147 96.92 Very High Very High Very High
Hypolipidemia 6 92.64 High High
Coronary Heart Disease 99 83.04 Quite High
Myocardial Infarction 57 5.00 Very Low Very Low Very Low
Cardiovascular Disease 33 5.00 Very Low Very Low Very Low
Nicotine Addiction 33 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, overexpression of ABCA1 in transgenic mice is associated with increased TC, HDL-C levels, and Apo AI with enhanced cholesterol efflux and reduced levels of atherogenesis (Brewer et al 2004).
ABCA1 Binding (associated) of HDL associated with targeted disruption, atherosclerosis and disorder of lipid metabolism
1) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.60 Pain Relevance 0
HDL, removes FC and PL from peripheral cells throughout the body by interacting with a membrane associated protein ubiquitously expressed in peripheral tissues, known as ATP-binding cassette transporter 1 (ABCA1).
ABCA1 Binding (interacting) of HDL in body associated with disorder of lipid metabolism
2) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.76 Pain Relevance 0
HDL receives PL and FC from peripheral cells by associating with the surface protein ABCA1 (Oram and Lawn 2001), which is expressed by the liver and intestinal mucosa.
ABCA1 Binding (associating) of HDL in liver associated with disorder of lipid metabolism
3) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.43 Pain Relevance 0

General Comments

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