INT239370

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 32.09
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (DNAJA1) protein folding (DNAJA1)
Anatomy Link Frequency
pancreas 3
acinar cells 1
epithelium 1
DNAJA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 27 100.00 Very High Very High Very High
Chronic pancreatitis 135 79.68 Quite High
agonist 112 69.48 Quite High
Inflammation 2 66.56 Quite High
imagery 7 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
dopamine receptor 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 432 100.00 Very High Very High Very High
Cancer 1009 99.84 Very High Very High Very High
Adenocarcinoma 1377 99.58 Very High Very High Very High
Pancreatitis 405 97.52 Very High Very High Very High
Malignant Neoplastic Disease 81 92.36 High High
Metastasis 27 92.20 High High
Disorder Of Lipid Metabolism 27 89.00 High High
INFLAMMATION 4 66.56 Quite High
Liver Cancer 27 51.60 Quite High
Bladder Cancer 27 48.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti HDJ-2 antibody was from Neomarkers.
Gene_expression (antibody) of HDJ-2
1) Confidence 0.65 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.07
We further confirmed the expression levels of three up-regulated proteins (MMP-9, DJ-1 and A1BG) in pancreatic juice, tissue and serum samples using Western blot, IHC or ELISA.
Gene_expression (expression) of DJ-1
2) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.28 Pain Relevance 0.16
As seen in Figure 3, compared with cancer-free controls, increased MMP-9, DJ-1 and A1BG expression in cancerous pancreatic juice were detected by Western blot.
Gene_expression (expression) of DJ-1 associated with cancer
3) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.68 Pain Relevance 0
The relationships with DJ-1, MMP-9 and A1BG expression and clinicopathological parameters were analyzed using Chi-square or Fisher's exact tests.
Gene_expression (expression) of DJ-1
4) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.33 Pain Relevance 0.06
Our immunohistological study extended the above investigation to larger sample size and revealed that MMP-9 and DJ-1 were expressed in 82.4% and 72.5% of PDAC tissues, significantly higher than that in normal pancreas.
Gene_expression (expressed) of DJ-1 in pancreas associated with adenocarcinoma
5) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.24 Pain Relevance 0
The expressions of MMP-9, DJ-1 and A1BG were confirmed by immunohistochemistry in 51 pancreatic cancer and 8 normal pancreas samples that were not included in the proteomic experiment (Table 4; Figure 4).
Gene_expression (expressions) of DJ-1 in pancreas associated with pancreatic cancer
6) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.83 Pain Relevance 0
Over-expression of MMP-9 and DJ-1 in pancreatic cancer tissues have been shown in previous studies [10,11].
Gene_expression (Over) of DJ-1 associated with pancreatic cancer
7) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.30 Pain Relevance 0
Western blot analysis demonstrated elevated protein levels of MMP-9, DJ-1 and A1BG in cancerous pancreatic juice compared with cancer-free pancreatic juice, which is consistent with our proteomic findings.
Gene_expression (levels) of DJ-1 associated with cancer
8) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.51 Pain Relevance 0
Moderately differentiated PDAC demonstrated a higher expression level of DJ-1 than poorly differentiated tumor subgroup, which suggests that DJ-1 may be a differentiation related protein.
Gene_expression (expression) of DJ-1 associated with adenocarcinoma and cancer
9) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.19 Pain Relevance 0
In PDAC, 72.5% demonstrated DJ-1 over-expression in cancer cells.
Gene_expression (over) of DJ-1 associated with adenocarcinoma and cancer
10) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.32 Pain Relevance 0
Furthermore, DJ-1 over-expression was associated with PDAC differentiation.
Gene_expression (over) of DJ-1 associated with adenocarcinoma
11) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.19 Pain Relevance 0
In normal pancreas, DJ-1 was negatively or weakly expressed in duct epithelium, acinar cells and islet cells.
Gene_expression (expressed) of DJ-1 in acinar cells
12) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.34 Pain Relevance 0
Western blot analysis of MMP-9, DJ-1 and A1BG
Gene_expression (analysis) of DJ-1
13) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.68 Pain Relevance 0
Over-expression of MMP-9 and DJ-1 in pancreatic cancer tissues have been shown in previous studies [10,11].
Gene_expression (expression) of DJ-1 associated with pancreatic cancer
14) Confidence 0.44 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.30 Pain Relevance 0
Recently, several previous studies have shown that DJ-1 is over-expressed in multiple cancer tissues including pancreatic cancer [15,16].
Gene_expression (expressed) of DJ-1 associated with cancer and pancreatic cancer
15) Confidence 0.44 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.21 Pain Relevance 0
Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients

Background

Gene_expression (overexpressed) of DJ-1 associated with adenocarcinoma
16) Confidence 0.44 Published 2008 Journal BMC Cancer Section Title Doc Link PMC2528014 Disease Relevance 0.80 Pain Relevance 0.03
Of the identified differently expressed proteins, three up-regulated proteins in pancreatic cancer juice, matrix metalloproteinase-9 (MMP-9), oncogene DJ1 (DJ-1) and alpha-1B-glycoprotein precursor (A1BG), were selected for validation by Western blot and immunohistochemistry.
Gene_expression (expressed) of DJ-1 associated with pancreatic cancer and metalloproteinase
17) Confidence 0.44 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2528014 Disease Relevance 0.93 Pain Relevance 0.05
Increased MMP-9, DJ-1 and A1BG expression in cancerous pancreatic juice were confirmed by Western blot.
Gene_expression (expression) of DJ-1
18) Confidence 0.44 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2528014 Disease Relevance 1.01 Pain Relevance 0.11
Immunohistochemical study showed MMP-9, DJ-1 and A1BG positively expressed in 82.4%, 72.5% and 86.3% of pancreatic cancer tissues, significantly higher than that in normal pancreas tissues.
Gene_expression (expressed) of DJ-1 in pancreas associated with pancreatic cancer
19) Confidence 0.44 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2528014 Disease Relevance 1.07 Pain Relevance 0.12
There was a significant difference of DJ-1 over-expression between moderately differentiated PDAC with poorly differentiated PDAC (p < 0.05).
Gene_expression (over) of DJ-1 associated with adenocarcinoma
20) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.39 Pain Relevance 0.06

General Comments

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