INT239373

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.98
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PTEN) cell proliferation (PTEN) cytosol (PTEN)
plasma membrane (PTEN) nucleus (PTEN) enzyme binding (PTEN)
Anatomy Link Frequency
cleavage 2
PTEN (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 21 95.44 Very High Very High Very High
cva 3 25.76 Quite Low
Inflammation 3 24.60 Low Low
Central nervous system 22 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 11 99.40 Very High Very High Very High
Basal And Squamous Cell Skin Cancer 71 99.00 Very High Very High Very High
Apoptosis 20 98.80 Very High Very High Very High
Cancer 209 98.68 Very High Very High Very High
Papillomavirus Infection 55 97.60 Very High Very High Very High
Lichen Sclerosus Et Atrophicus 32 91.80 High High
Carcinoma 3 89.76 High High
Malignant Neoplastic Disease 8 84.64 Quite High
Advanced Or Metastatic Breast Cancer 28 80.92 Quite High
Microsatellite Instability 6 76.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
of IkB, induction of TSC22, NF-kB, GADD153, PTEN, etc.) may depend on the
Spec (may) Positive_regulation (depend) of Positive_regulation (induction) of PTEN
1) Confidence 0.25 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.80 Pain Relevance 0
TZDs

induced upregulation of PTEN and p21, downregulation of cyclins D and E, and

Positive_regulation (induced) of Positive_regulation (upregulation) of PTEN
2) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 1.38 Pain Relevance 0.12
Somatic mutation of PTEN was also demonstrated in some cases of vulvar SCC and VIN, suggesting that PTEN mutation possibly played a role early in the carcinogenesis of vulvar SCC [37].
Positive_regulation (demonstrated) of Positive_regulation (mutation) of PTEN associated with cancer and basal and squamous cell skin cancer
3) Confidence 0.18 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 2.54 Pain Relevance 0
Despite documented HER2 receptor amplification, patients may have de novo or acquired resistance to trastuzumab. 39 Potential mechanisms of trastuzumab resistance include altered receptor┬ľantibody interaction (MUC4, p95HER2, ErbB2 mutations), altered downstream signaling (reduced p27, reduced PTEN, activation of PI3K, activation of Akt) and crosstalk with other signaling pathways (IGF-R1, ER, VEGFR).40 The p95HER2 receptor is created either by cleavage and shedding of the extracellular domain of the HER2 receptor or by specific mRNA splicing, resulting in a constitutively active truncated receptor which is associated with a more aggressive phenotype.
Positive_regulation (activation) of Positive_regulation (activation) of PTEN in cleavage
4) Confidence 0.12 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.26 Pain Relevance 0

General Comments

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