INT23938

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Context Info
Confidence 0.45
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 9.82
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (EDNRA) signal transduction (EDNRA) aging (EDNRA)
plasma membrane (EDNRA) signal transducer activity (EDNRA)
Anatomy Link Frequency
plasma 2
H69AR 2
ovaries 2
EDNRA (Homo sapiens)
Pain Link Frequency Relevance Heat
analgesia 10 91.80 High High
agonist 3 90.72 High High
Pain 32 89.52 High High
antagonist 145 87.80 High High
Pain refractory 5 83.80 Quite High
Opioid 5 81.16 Quite High
lidocaine 1 77.72 Quite High
nociceptor 10 76.44 Quite High
vincristine 1 67.56 Quite High
Inflammatory response 7 59.64 Quite High
Disease Link Frequency Relevance Heat
Cancer 328 99.88 Very High Very High Very High
Breast Cancer 40 99.84 Very High Very High Very High
Reprotox - General 1 80 99.76 Very High Very High Very High
Prostate Cancer 5 99.76 Very High Very High Very High
Death 15 99.72 Very High Very High Very High
Injury 248 99.52 Very High Very High Very High
Papillomavirus Infection 20 99.06 Very High Very High Very High
Ovarian Cancer 115 99.02 Very High Very High Very High
Metastasis 65 96.24 Very High Very High Very High
Immunotherapy Of Cancer 10 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human papillomavirus (HPV)-positive human cervical carcinoma cell lines overexpress ET-1 and ETAR mRNA and secrete ET-1 protein compared to HPV-negative cells.
Positive_regulation (overexpress) of Gene_expression (overexpress) of ETAR mRNA associated with papillomavirus infection and reprotox - general 1
1) Confidence 0.45 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 2.32 Pain Relevance 0.13
Increased ETAR expression is also seen with advancing tumor stage and grade in both primary and metastatic prostate cancer.
Positive_regulation (Increased) of Gene_expression (expression) of ETAR associated with cancer and reprotox - general 1
2) Confidence 0.45 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.25 Pain Relevance 0.04
ET-1 and its receptors, ETAR and ETBR, are overexpressed in breast carcinomas.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ETAR associated with breast cancer
3) Confidence 0.45 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.60 Pain Relevance 0.10
These findings demonstrating the antitumor, anti-angiogenic, apoptotic activities of ABT-627 in vivo provide a rationale for the clinical evaluation of this molecule, alone and in combination with other therapies, in patients with ovarian tumors and potentially in other epithelial tumors that overexpress functional ETAR.


Positive_regulation (overexpress) of Gene_expression (overexpress) of ETAR associated with cancer, ovarian cancer and apoptosis
4) Confidence 0.39 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.16 Pain Relevance 0
ET-1/ETAR autocrine pathway is overexpressed in primary and metastatic ovarian carcinomas, compared with normal ovaries (15).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ETAR in ovaries associated with ovarian cancer
5) Confidence 0.32 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.53 Pain Relevance 1.02
Thus, unlike most multidrug resistant cell lines, H69AR does not appear to express enhanced levels of P-glycoprotein.
Positive_regulation (enhanced) of Gene_expression (express) of H69AR in H69AR
6) Confidence 0.25 Published 1987 Journal Cancer Res. Section Abstract Doc Link 2436751 Disease Relevance 0.13 Pain Relevance 0.11
In rat models of AKI, circulating levels of endothelin-1 and tissue expression of endothelin-1 protein levels was substantially increased, while ET(A) and ET(B) receptor gene expression was also increased after ischemic injury [41].
Positive_regulation (increased) of Gene_expression (expression) of endothelin associated with injury
7) Confidence 0.08 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.56 Pain Relevance 0.08
Upon these observations we believed that possible reason for higher plasma ET levels of osteoporotic men then the normal men in our study may be because of the lower bioavaliable estrogen concentration of the males in these ages and as a result possible decrease of estrogens effect in down regulation in ET and consequently increase of ET amount and effects.
Positive_regulation (increase) of Gene_expression (amount) of ET in plasma
8) Confidence 0.03 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1242236 Disease Relevance 0.28 Pain Relevance 0

General Comments

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