INT239386

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.24
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Atp7b) cytoplasmic membrane-bounded vesicle (Atp7b) plasma membrane (Atp7b)
Anatomy Link Frequency
neutrophil 1
Atp7b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 30 99.96 Very High Very High Very High
cva 12 91.24 High High
cytokine 6 42.36 Quite Low
ischemia 12 39.52 Quite Low
anesthesia 23 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 48 100.00 Very High Very High Very High
INFLAMMATION 18 99.96 Very High Very High Very High
Pneumonia 12 99.52 Very High Very High Very High
Adult Respiratory Distress Syndrome 129 96.48 Very High Very High Very High
Infection 18 94.56 High High
Hemorrhage 6 91.24 High High
Injury 57 89.92 High High
Lung Injury 66 60.52 Quite High
Hemorrhagic Shock 9 48.48 Quite Low
Retinal Diseases 4 47.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, while HTS reduced indices of pulmonary inflammation, it not attenuate the severity of oleic acid induced ALI.


Gene_expression (reduced) of HTS associated with inflammation, adult respiratory distress syndrome and pneumonia
1) Confidence 0.52 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 1.44 Pain Relevance 0.16
HTS significantly reduced BAL neutrophil counts [Figure 4], and BAL IL-6 concentrations [Figure 5] compared to control conditions.
Gene_expression (reduced) of HTS in neutrophil
2) Confidence 0.52 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 0.39 Pain Relevance 0.08
BAL protein levels were reduced with HTS, although these differences were not statistically significant [Table 2].
Gene_expression (reduced) of HTS
3) Confidence 0.52 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 0.44 Pain Relevance 0.07
Transfection data, quantitative RT-PCR, and flow cytometry show that around 85% of expression from the CMV promoter was blocked by the TB element, allowing direct evaluation of expression from the Vim409 candidate promoter cloned into the MCS.
Gene_expression (expression) of CMV promoter associated with cytomegalovirus infection
4) Confidence 0.01 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2765473 Disease Relevance 0.48 Pain Relevance 0
We tested and determined that a TB element is effective at mitigating the majority (about 85%) of transgene expression from the CMV promoter (Figure 2).
Gene_expression (expression) of CMV promoter associated with cytomegalovirus infection
5) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765473 Disease Relevance 0.49 Pain Relevance 0

General Comments

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