INT239411

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.71
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (APOB) small molecule metabolic process (APOB) endoplasmic reticulum (APOB)
enzyme binding (APOB) lipid metabolic process (APOB) extracellular space (APOB)
Anatomy Link Frequency
fat 1
hepatocytes 1
neutrophil 1
APOB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 35 84.72 Quite High
depression 2 47.28 Quite Low
Pain 12 31.12 Quite Low
Demyelination 5 7.36 Low Low
imagery 10 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 75 100.00 Very High Very High Very High
Bacterial Respiratory Disease 3 100.00 Very High Very High Very High
Disease 203 99.98 Very High Very High Very High
Rare Diseases 3 98.06 Very High Very High Very High
Familial Combined Hyperlipidemia 127 97.60 Very High Very High Very High
Coronary Artery Disease 86 97.28 Very High Very High Very High
Increased Venous Pressure Under Development 12 91.04 High High
Diarrhoea 12 86.92 High High
INFLAMMATION 39 84.72 Quite High
Syndrome 11 81.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the low serum levels of fat soluble vitamins continue, because the plasma transport and delivery of these vitamins to tissues depends almost exclusively (for vitamin E and beta-carotene) or in part (for vitamins A, D, and K) on intact synthesis and secretion of apo B-containing lipoproteins.
Localization (secretion) of apo B in fat
1) Confidence 0.76 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.67 Pain Relevance 0
ApoB100 is the major apolipoprotein found in LDL, intermediate-density lipoprotein (IDL), and very low-density lipoprotein (VLDL), and it is the primary ligand for the LDL receptor.
Localization (found) of ApoB100 associated with disorder of lipid metabolism
2) Confidence 0.73 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2742703 Disease Relevance 0.74 Pain Relevance 0
In 1986, the APOB gene, its mRNA and the apo B content of the hepatocytes were found to be normal in ABL patients, suggesting that defective post-translational processing and secretion of apo B was the cause of ABL [3].
Localization (secretion) of apo B in hepatocytes
3) Confidence 0.66 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.68 Pain Relevance 0
In summary, ABL is a rare disease of lipoprotein metabolism that has drawn attention to the importance of MTP in the assembly and secretion of apo B-containing lipoproteins.
Localization (secretion) of apo B associated with rare diseases
4) Confidence 0.66 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.51 Pain Relevance 0
6; ApoB correlation?
Localization (correlation) of ApoB
5) Confidence 0.46 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 1.09 Pain Relevance 0
With respect to the extracellular components, serum proteins, such as albumin, IgG3 and apolipoprotein B-100; as well as proteins displaying antibacterial properties, such as neutrophil defensin, cystatins B and S and Annexins A1 and A3, were found.
Localization (found) of apolipoprotein B-100 in neutrophil associated with bacterial respiratory disease and disorder of lipid metabolism
6) Confidence 0.35 Published 2010 Journal Journal of Proteome Research Section Body Doc Link PMC2950674 Disease Relevance 0.56 Pain Relevance 0
HDL-C is measured after precipitation of the apolipoprotein B containing lipoproteins with phosphotungistic acid.
Localization (precipitation) of apolipoprotein B associated with disorder of lipid metabolism
7) Confidence 0.10 Published 2009 Journal Trials Section Body Doc Link PMC2656492 Disease Relevance 0.38 Pain Relevance 0
Atorvastatin decreases hepatic apo B secretion, which lowers VLDL production (Conde et al 1996).
Localization (secretion) of apo B
8) Confidence 0.07 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546474 Disease Relevance 0.23 Pain Relevance 0.04
Rab7 disease mutant localization is distinct from constitutively active Rab7
Localization (localization) of mutant associated with disease
9) Confidence 0.01 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.59 Pain Relevance 0
We also used an unbiased approach to interrogate the protein interactors of wild-type and mutant forms of Rab7.
Localization (forms) of mutant
10) Confidence 0.01 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.26 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox