INT239464

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.37
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
neurite 2
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 17 88.64 High High
Serotonin 3 85.28 High High
Dopamine 69 69.28 Quite High
cytokine 4 68.72 Quite High
Neurotransmitter 9 59.20 Quite High
imagery 17 14.16 Low Low
agonist 31 5.00 Very Low Very Low Very Low
antagonist 18 5.00 Very Low Very Low Very Low
dopamine receptor 10 5.00 Very Low Very Low Very Low
nalbuphine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 6 76.72 Quite High
Neurodegenerative Disease 1 72.72 Quite High
Schizophrenia 3 39.28 Quite Low
Increased Venous Pressure Under Development 4 10.68 Low Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Heart Rate Under Development 5 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Sepsis 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the EDL, the total protein level of AKT was unaffected by a 24 h LPS infusion (Fig. 4A), although a trend (P?
Neg (unaffected) Regulation (unaffected) of Neg (unaffected) Negative_regulation (unaffected) of AKT
1) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0.03
Direct inhibition of Akt suppressed mitochondrial trafficking, whereas inhibition of GSK3?
Regulation (Direct) of Negative_regulation (inhibition) of Akt
2) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0.37 Pain Relevance 0.14
We next examined the effect of this Akt inhibitor on neurite outgrowth of PC12 (WT-Akt) cells.
Spec (examined) Regulation (effect) of Spec (examined) Negative_regulation (inhibitor) of Akt in neurite
3) Confidence 0.15 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.08

General Comments

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