INT239482

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.06
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Spna1) molecular_function (Spna1) cytoplasm (Spna1)
Anatomy Link Frequency
fibroblasts 4
neurons 2
brain 2
synovium 2
Spna1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 112 97.24 Very High Very High Very High
Hippocampus 32 95.88 Very High Very High Very High
Analgesic 4 90.56 High High
corticosteroid 4 88.00 High High
Locus ceruleus 12 83.16 Quite High
cytokine 16 82.64 Quite High
Substantia nigra 2 82.32 Quite High
Dopamine 2 79.04 Quite High
Osteoarthritis 4 75.00 Quite High
gABA 26 63.52 Quite High
Disease Link Frequency Relevance Heat
Disease 196 100.00 Very High Very High Very High
Hyperplasia 20 99.90 Very High Very High Very High
Neurodegenerative Disease 24 98.12 Very High Very High Very High
Cognitive Disorder 82 97.88 Very High Very High Very High
Fibrosis 120 97.24 Very High Very High Very High
Influenza Virus Infection 148 88.92 High High
Targeted Disruption 32 86.96 High High
Generalized Anxiety Disorder 6 86.16 High High
Immunization 68 85.44 High High
Pox Virus Infection 23 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The brain HA production in the 3xTg-AD mice was increased by feeding them with a vitamin B6-deficient diet for 3 weeks.
Positive_regulation (increased) of Gene_expression (production) of HA in brain associated with disease
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.15 Pain Relevance 0.11
Then why did the HA level increase in 3xTg-AD mice?
Positive_regulation (increase) of Gene_expression (level) of HA associated with disease
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.12 Pain Relevance 0
secreting cells upon stimulation with H5 HA peptide pools corresponding to both HA1 and HA2 subunits of H5 HA as compared to those of H5-naive mice at the time of viral antigen challenge with inactivated rg?
Positive_regulation (stimulation) of Gene_expression (pools) of HA peptide
3) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.40 Pain Relevance 0.08
It therefore appears that, in the same way that endogenous norepinephrine is not essential for the firing of NE neurons, endogenous histamine is not necessary for the expression of the firing properties of HA neurons.
Neg (not) Positive_regulation (necessary) of Gene_expression (expression) of HA in neurons
4) Confidence 0.12 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0.09 Pain Relevance 0.24
As shown in Fig. 1A, the viruses with HA gene inserts induced high level expression of HA in avian DF-1 cells.
Positive_regulation (induced) of Gene_expression (expression) of HA
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.48 Pain Relevance 0
Accordingly, an increase in HA transmission promotes W, whereas its blockade causes somnolence and increased cortical slow activity (Schwartz et al., 1991; Monti, 1993; Lin, 2000; Yanai and Tashiro, 2007).
Positive_regulation (increase) of Gene_expression (transmission) of HA
6) Confidence 0.10 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0.26 Pain Relevance 0.09
When HA and NP were present, significant humoral responses were stimulated against these proteins.
Positive_regulation (When) of Gene_expression (present) of HA
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.60 Pain Relevance 0
Previously, we showed that acute application of non-derivatized HA in vitro increased endogenous HA synthesis by synovial fibroblasts, which was dependent on the MW of the HA preparation.
Positive_regulation (increased) of Gene_expression (synthesis) of HA in fibroblasts
8) Confidence 0.02 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 0.14 Pain Relevance 0.10
Various preparations of HA with a range of MWs differentially stimulated synthesis of HMW HA by synovial biopsy cells in culture [23].
Positive_regulation (stimulated) of Gene_expression (synthesis) of HA
9) Confidence 0.02 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 0.09 Pain Relevance 0.04
The enhanced ability of HYADD4-G to remain in the joint cavity and hence in contact with the synovium could account for its more potent effects on the MW of endogenous HA production by synovial fibroblasts isolated 5 weeks after the last injection.
Positive_regulation (account) of Gene_expression (production) of HA in synovium
10) Confidence 0.02 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 0.18 Pain Relevance 0.17
HYADD®4-G treatment decreased vascularity, intimal hyperplasia and increased high-molecular weight HA synthesis by synovial fibroblasts.
Positive_regulation (increased) of Gene_expression (synthesis) of HA in fibroblasts associated with hyperplasia
11) Confidence 0.02 Published 2008 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2468886 Disease Relevance 0.53 Pain Relevance 0.22

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