INT239494

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.15
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 35 99.28 Very High Very High Very High
Glutamate receptor 20 96.64 Very High Very High Very High
Glutamate 33 91.92 High High
opioid receptor 1 60.24 Quite High
adenocard 14 56.64 Quite High
Opioid 1 54.16 Quite High
headache 1 38.40 Quite Low
Calcium channel 4 35.28 Quite Low
Spinal cord 1 34.92 Quite Low
Inflammation 4 13.60 Low Low
Disease Link Frequency Relevance Heat
Hypoxia 146 94.44 High High
Rheumatoid Arthritis 15 88.36 High High
Increased Venous Pressure Under Development 2 65.48 Quite High
Vomiting 5 56.96 Quite High
Diarrhoea 1 55.36 Quite High
American Trypanosomiasis 8 50.00 Quite Low
Disease 9 48.36 Quite Low
Toxicity 5 41.28 Quite Low
Headache 1 38.40 Quite Low
Pneumonia 1 36.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MTX responder: defined as patients who fulfilled three criteria—physician statement of good response and ESR ?
Regulation (fulfilled) of Localization (response) of ESR associated with methotrexate
1) Confidence 0.19 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.39 Pain Relevance 0.42
Given our observations, it would be interesting to study the effect of ER calcium mobilization on the fate of steroid-activated nuclear receptors.
Regulation (effect) of Localization (mobilization) of ER
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
We cannot, however, exclude the possibility that other mechanisms also contribute to ER Ca2+ release.
Spec (possibility) Regulation (contribute) of Localization (release) of ER
3) Confidence 0.03 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.75 Pain Relevance 0
The AMPA-Rs are not the first membrane receptor whose folding and ER export are modulated by the ligands and co-factors.
Regulation (modulated) of Localization (export) of ER
4) Confidence 0.02 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.30
Aborted ER translocation would operate during the first steps of protein synthesis and the C-terminal-truncated TcCRT and the full length protein should be expected to behave similarly.
Regulation (operate) of Localization (translocation) of ER
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0

General Comments

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