INT239495

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.55
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtx1)
Anatomy Link Frequency
blood 4
Mtx1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 596 100.00 Very High Very High Very High
rheumatoid arthritis 65 94.44 High High
cINOD 51 94.40 High High
Arthritis 308 89.80 High High
aspirin 6 88.12 High High
Bioavailability 3 68.24 Quite High
adenocard 14 58.20 Quite High
Inflammation 19 50.00 Quite Low
headache 10 31.52 Quite Low
agonist 2 13.56 Low Low
Disease Link Frequency Relevance Heat
Toxicity 17 99.80 Very High Very High Very High
Rheumatoid Arthritis 80 94.44 High High
Arthritis 57 89.80 High High
Juvenile Chronic Polyarthritis 264 83.76 Quite High
Leukemia 3 50.32 Quite High
Vomiting 20 50.08 Quite High
INFLAMMATION 24 50.00 Quite Low
Disease 82 49.92 Quite Low
Diarrhoea 7 48.48 Quite Low
Headache 10 31.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relationship between blood MTX level and toxicity
Negative_regulation (Relationship) of Gene_expression (level) of MTX in blood associated with toxicity and methotrexate
1) Confidence 0.36 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.46 Pain Relevance 0.63
However, no significant change was noted in MTX clearance (10.6 ± 5.5 vs. 13.1 ± 3.5 L/h, P = 0.19), AUC (2.1 ± 1.0 ?
Negative_regulation (noted) of Gene_expression (clearance) of MTX associated with methotrexate
2) Confidence 0.36 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.35 Pain Relevance 1.33
Relationship between blood MTX level and toxicity
Negative_regulation (blood) of Gene_expression (level) of MTX in blood associated with toxicity and methotrexate
3) Confidence 0.36 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.46 Pain Relevance 0.62
MTX responder: defined as patients who fulfilled three criteria—physician statement of good response and ESR ?
Negative_regulation (defined) of Gene_expression (responder) of MTX associated with methotrexate
4) Confidence 0.32 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.28 Pain Relevance 0.38
There was also a trend for female patients to be more likely to stop MTX for adverse events (79% vs 64%, p?
Negative_regulation (events) of Gene_expression (stop) of MTX associated with methotrexate
5) Confidence 0.19 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2596302 Disease Relevance 0 Pain Relevance 0.28

General Comments

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