INT239496

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.45
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Aes)
Anatomy Link Frequency
neurons 1
arms 1
Aes (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 70 99.84 Very High Very High Very High
depression 2 93.08 High High
headache 2 78.72 Quite High
Pyramidal cell 4 68.80 Quite High
cva 4 60.00 Quite High
adenocard 28 50.00 Quite Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 30 99.36 Very High Very High Very High
Vomiting 12 97.28 Very High Very High Very High
Diarrhoea 5 95.68 Very High Very High Very High
Depression 2 93.08 High High
Fatigue 6 85.20 High High
Asthenia 1 84.24 Quite High
Toxicity 22 81.60 Quite High
Headache 2 78.72 Quite High
Pneumonia 2 77.04 Quite High
Wound Healing 2 62.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, we report a novel association between ADORA2a polymorphisms and AEs in MTX-treated RA patients.
Gene_expression (polymorphisms) of AEs associated with rheumatoid arthritis and methotrexate
1) Confidence 0.52 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.24 Pain Relevance 0.21
AEs were further divided into subtypes:
Gene_expression (divided) of AEs
2) Confidence 0.52 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.65 Pain Relevance 0.44
However, unisensory areas in different parts of AES project to the SC in this species (Wallace et al., 1993), and it is their convergence onto individual SC neurons that appears to synergistically create multisensory enhancement or depression depending on the proximity of stimuli in different sensory modalities (Alvarado et al., 2007, 2009).
Gene_expression (project) of AES in neurons associated with depression
3) Confidence 0.09 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2904598 Disease Relevance 0.09 Pain Relevance 0.08
3 AEs (bevacizumab 66%; IFN 48%) was observed in both treatment arms in patients aged ?
Gene_expression (observed) of AEs in arms
4) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 0.47 Pain Relevance 0.03

General Comments

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