INT239497

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.61
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Aes)
Aes (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 245 99.84 Very High Very High Very High
Inflammation 79 99.28 Very High Very High Very High
adenocard 98 81.28 Quite High
cva 34 80.56 Quite High
headache 9 66.72 Quite High
central sensitization 7 28.64 Quite Low
Central nervous system 21 24.56 Low Low
antagonist 19 16.24 Low Low
agonist 14 5.00 Very Low Very Low Very Low
Arthritis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Toxicity (including Many Sub-types) 96 100.00 Very High Very High Very High
Cataract 14 99.76 Very High Very High Very High
INFLAMMATION 86 99.28 Very High Very High Very High
Rheumatoid Arthritis 105 99.00 Very High Very High Very High
Hyperkalemia 8 85.96 High High
Cv General 3 Under Development 8 80.56 Quite High
Ocular Hypertension 24 80.52 Quite High
Chronic Renal Failure 64 75.68 Quite High
Renal Disease 23 75.48 Quite High
Pressure And Volume Under Development 17 69.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies are, however, needed to determine the positive predictive value of these polymorphisms and determine whether there is any association with patients who experience but tolerate milder AEs.
AEs Spec (whether) Binding (association) of
1) Confidence 0.29 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.15 Pain Relevance 0.09
Even applying the more stringent corrected permutation P-values (EMP2 in Table 1); two of the SNPs remained significantly associated with AEs.
AEs Binding (associated) of
2) Confidence 0.29 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.06 Pain Relevance 0
The AE group was then stratified by type and a consistent association was observed between gastrointestinal (GI) AEs and all five SNPs (Table 1).
AEs Binding (association) of
3) Confidence 0.29 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.06 Pain Relevance 0
All five SNPs were significantly associated with AEs (Table 1).
AEs Binding (associated) of
4) Confidence 0.29 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.06 Pain Relevance 0
Specifically, associations were observed between several ADORA2a SNPs and GI AEs on MTX.
AEs Binding (associations) of associated with methotrexate
5) Confidence 0.29 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.25 Pain Relevance 0.22
Overall, these SNPs were significantly associated with any AEs at all five loci (OR 2.1–3.07, P < 0.05 for all).
AEs Binding (associated) of
6) Confidence 0.28 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.07 Pain Relevance 0.16
In subgroup analysis, carriage of the variant allele was significantly associated with GI AEs at two of the five loci.
AEs Binding (associated) of
7) Confidence 0.28 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.14 Pain Relevance 0.22
With the exception of one severe cataract formation in the verteporfin PDT group, all AEs associated with cataracts were mild or moderate (Brown et al. 2006).


AEs Binding (associated) of associated with ocular toxicity (including many sub-types) and cataract
8) Confidence 0.16 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.32 Pain Relevance 0.04
Proportionately more ranibizumab-treated patients who were immunoreactive at any point during ANCHOR had AEs associated with intraocular inflammation, although the small number of patients with immunoreactivity precludes drawing definitive conclusions (Brown et al. 2006).
AEs Binding (associated) of associated with inflammation and ocular toxicity (including many sub-types)
9) Confidence 0.15 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 0.35 Pain Relevance 0.05
These studies suggest that the AEs associated with aliskiren alone or in combination with ARBs are generally mild and similar to current therapies.
AEs Binding (associated) of
10) Confidence 0.13 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 1.14 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox