INT239497

Context Info Confidence 0.29 First Reported 2007 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 8 Total Number 10 Disease Relevance 3.61 Pain Relevance 0.84

nucleus (Aes)

Aes (Mus musculus)

Pain Link Frequency Relevance Heat methotrexate 245 99.84 Inflammation 79 99.28 adenocard 98 81.28 cva 34 80.56 headache 9 66.72 central sensitization 7 28.64 Central nervous system 21 24.56 antagonist 19 16.24 agonist 14 5.00 Arthritis 7 5.00

Disease Link Frequency Relevance Heat Ocular Toxicity (including Many Sub-types) 96 100.00 Cataract 14 99.76 INFLAMMATION 86 99.28 Rheumatoid Arthritis 105 99.00 Hyperkalemia 8 85.96 Cv General 3 Under Development 8 80.56 Ocular Hypertension 24 80.52 Chronic Renal Failure 64 75.68 Renal Disease 23 75.48 Pressure And Volume Under Development 17 69.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further studies are, however, needed to determine the positive predictive value of these polymorphisms and determine whether there is any association with patients who experience but tolerate milder AEs.

AEs Spec (whether) Binding (association) of

1) Confidence 0.29 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.15 Pain Relevance 0.09

Even applying the more stringent corrected permutation P-values (EMP2 in Table 1); two of the SNPs remained significantly associated with AEs.

AEs Binding (associated) of

2) Confidence 0.29 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.06 Pain Relevance 0

The AE group was then stratified by type and a consistent association was observed between gastrointestinal (GI) AEs and all five SNPs (Table 1).

AEs Binding (association) of

3) Confidence 0.29 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.06 Pain Relevance 0

All five SNPs were significantly associated with AEs (Table 1).

AEs Binding (associated) of

4) Confidence 0.29 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.06 Pain Relevance 0

Specifically, associations were observed between several ADORA2a SNPs and GI AEs on MTX.

AEs Binding (associations) of associated with methotrexate

5) Confidence 0.29 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.25 Pain Relevance 0.22

Overall, these SNPs were significantly associated with any AEs at all five loci (OR 2.1–3.07, P < 0.05 for all).

AEs Binding (associated) of

6) Confidence 0.28 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.07 Pain Relevance 0.16

In subgroup analysis, carriage of the variant allele was significantly associated with GI AEs at two of the five loci.

AEs Binding (associated) of

7) Confidence 0.28 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.14 Pain Relevance 0.22

With the exception of one severe cataract formation in the verteporfin PDT group, all AEs associated with cataracts were mild or moderate (Brown et al. 2006).

AEs Binding (associated) of associated with ocular toxicity (including many sub-types) and cataract

8) Confidence 0.16 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 1.32 Pain Relevance 0.04

Proportionately more ranibizumab-treated patients who were immunoreactive at any point during ANCHOR had AEs associated with intraocular inflammation, although the small number of patients with immunoreactivity precludes drawing definitive conclusions (Brown et al. 2006).

AEs Binding (associated) of associated with inflammation and ocular toxicity (including many sub-types)

9) Confidence 0.15 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 0.35 Pain Relevance 0.05

These studies suggest that the AEs associated with aliskiren alone or in combination with ARBs are generally mild and similar to current therapies.

AEs Binding (associated) of

10) Confidence 0.13 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 1.14 Pain Relevance 0.07

General Comments

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