INT2395

Context Info Confidence 0.36 First Reported 1979 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 18 Total Number 19 Disease Relevance 7.53 Pain Relevance 0.68

transport (MB)

Anatomy Link Frequency plasma 7 developmental stages 1 urine 1 MB (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 16 93.96 Angina 9 88.44 Lasting pain 4 70.16 Thalamus 4 60.32 Inflammation 35 47.12 cytokine 6 40.16 alcohol 45 28.08 Pain 47 5.00 qutenza 19 5.00 cocaine 12 5.00

Disease Link Frequency Relevance Heat Malaria 396 100.00 Myoglobinuria 8 98.68 Disorders Of Creatine Metabolism 38 98.48 Myocardial Infarction 8 98.20 Acute Renal Failure 50 96.96 Rhabdomyolysis 200 96.40 Injury 70 96.20 Renal Failure 30 94.68 Cv Unclassified Under Development 14 93.96 Bites And Stings 154 93.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

[Radioimmunoassay for human myoglobin: methodology and diagnostic significance in myocardial infarction (author's transl)].

myoglobin Binding ([Radioimmunoassay) of associated with myocardial infarction

1) Confidence 0.36 Published 1979 Journal Klin. Wochenschr. Section Title Doc Link 431032 Disease Relevance 0.72 Pain Relevance 0.53

Myoglobin in the renal glomerular filtrate can precipitate and cause renal tubular obstruction, leading to renal damage [57].

Myoglobin Binding (leading) of

2) Confidence 0.19 Published 2005 Journal Crit Care Section Body Doc Link PMC1175909 Disease Relevance 1.72 Pain Relevance 0.05

A urine dipstick is a quick way to screen for myoglobinuria, as the reagent on the dipstick that reacts with hemoglobin also reacts with myoglobin [18].

myoglobin Binding (reacts) of in urine associated with myoglobinuria

3) Confidence 0.16 Published 2005 Journal Crit Care Section Body Doc Link PMC1175909 Disease Relevance 1.06 Pain Relevance 0

It is possible that, the quantitative difference of inoculated sporozoites is responsible for the difference observed in antibody recognition against MB2 between protected volunteers and persons living in endemic countries.

MB2 Binding (recognition) of

4) Confidence 0.12 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0.54 Pain Relevance 0

Since MB2 was shown to be present in multiple developmental stages including the hepatic stage that can be recognized by CTLs, it will be important to obtain evidence that MB2 also is recognized by CTLs from P. falciparum-exposed individuals.

MB2 Binding (recognized) of in developmental stages

5) Confidence 0.12 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0.19 Pain Relevance 0

It binds oxygen with an affinity between that of myoglobin and hemoglobin [3,4].

myoglobin Binding (binds) of

6) Confidence 0.10 Published 2005 Journal Proteome Sci Section Body Doc Link PMC554085 Disease Relevance 0.30 Pain Relevance 0.10

In contrast, two regions of the acidic domain, one of which contains amino acid repeats, were recognized strongly by the antibodies in the endemic plasma (MB2-D & MB2-E).

MB2 Binding (recognized) of in plasma

7) Confidence 0.09 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0.09 Pain Relevance 0

Furthermore, antibodies from the serum of protected volunteers recognized preferentially the non-repeat-containing MB2-B peptide, while the repeat-containing MB2-C peptide is recognized preferentially by the antibodies in the plasma of persons living in malaria-endemic areas.

MB2 Binding (recognized) of in plasma associated with malaria

8) Confidence 0.09 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0.10 Pain Relevance 0

Immunoblot analyses using serum of a volunteer protected by the exposure to non-replicating metabolically active sporozoites (#5) revealed that linear epitopes within the basic domain of MB2 are recognized strongly, whilst the acidic domain is recognized poorly.

MB2 Binding (recognized) of

9) Confidence 0.09 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0 Pain Relevance 0

Sera from protected volunteers preferentially recognized a non-repeat region of the basic domain of MB2, whereas plasma from naturally-infected individuals also had antibodies that recognize regions of MB2 that contain a repeat motif in immunoblots.

MB2 Binding (recognized) of in plasma

10) Confidence 0.09 Published 2009 Journal Malar J Section Abstract Doc Link PMC2772840 Disease Relevance 0.45 Pain Relevance 0

Antibodies from protected volunteers preferentially recognized a non-repeat region of the basic domain of MB2, whereas plasma from naturally-infected individuals had antibodies that recognize regions of MB2 that contain a repeat motif.

MB2 Binding (recognized) of in plasma

11) Confidence 0.09 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0.39 Pain Relevance 0

It would appear that serum from this protected (#5) individual reacts preferentially with MB2-B (non-repeat containing) and to a lesser degree with the MB2-C (repeat containing) region.

MB2 Binding (reacts) of

12) Confidence 0.09 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0 Pain Relevance 0

Furthermore, antibodies from the serum of protected volunteers recognized preferentially the non-repeat-containing MB2-B peptide, while the repeat-containing MB2-C peptide is recognized preferentially by the antibodies in the plasma of persons living in malaria-endemic areas.

MB2 Binding (recognized) of in plasma associated with malaria

13) Confidence 0.09 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0.09 Pain Relevance 0

One of the striking observations is that protected volunteers were able to recognize preferentially the non-repeat MB2-B and to a lesser degree the repeat-including MB2-C and -D regions that most naturally exposed persons in malaria-endemic areas recognize.

MB2 Binding (recognize) of associated with malaria

14) Confidence 0.08 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0.43 Pain Relevance 0

Antibodies from protected volunteers preferentially recognized a non-repeat region of the basic domain of MB2, whereas plasma from naturally-infected individuals had antibodies that recognize regions of MB2 that contain a repeat motif.

MB2 Binding (recognize) of in plasma

15) Confidence 0.08 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0.38 Pain Relevance 0

Sera from protected volunteers preferentially recognized a non-repeat region of the basic domain of MB2, whereas plasma from naturally-infected individuals also had antibodies that recognize regions of MB2 that contain a repeat motif in immunoblots.

MB2 Binding (recognize) of in plasma

16) Confidence 0.08 Published 2009 Journal Malar J Section Abstract Doc Link PMC2772840 Disease Relevance 0.46 Pain Relevance 0

Formation of metmyoglobin has a maximal rate in meat where the partial oxygen pressure makes oxymyoglobin and myoglobin concentrations equal due to the dominating bimolecular electron transfer to oxygen to yield hydrogen peroxide:(183)

myoglobin Binding (concentrations) of

17) Confidence 0.05 Published 2010 Journal Chemical Reviews Section Body Doc Link PMC2855180 Disease Relevance 0.07 Pain Relevance 0

In Norway it was legal and a common practice until very recently to pack meat in an atmosphere with a low level of carbon monoxide, which binds very strongly to iron(II) myoglobin.(181) Carbonylmyoglobin is intensely red and does not oxidize to metmyoglobin under normal conditions, so the meat products have a remarkable color stability, which was appreciated in the country with its many remote and small societies and difficult transportation of foods.

myoglobin Binding (binds) of

18) Confidence 0.04 Published 2010 Journal Chemical Reviews Section Body Doc Link PMC2855180 Disease Relevance 0 Pain Relevance 0

Nitrites and nitrates are used in meat because they bind to myoglobin, inhibiting botulinum exotoxin production; however, they are powerful carcinogens (46).

myoglobin Binding (bind) of

19) Confidence 0.02 Published 2008 Journal Pharm Res Section Body Doc Link PMC2515569 Disease Relevance 0.52 Pain Relevance 0

General Comments

This test has worked.