INT2395
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
[Radioimmunoassay for human myoglobin: methodology and diagnostic significance in myocardial infarction (author's transl)]. | |||||||||||||||
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Myoglobin in the renal glomerular filtrate can precipitate and cause renal tubular obstruction, leading to renal damage [57].
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A urine dipstick is a quick way to screen for myoglobinuria, as the reagent on the dipstick that reacts with hemoglobin also reacts with myoglobin [18]. | |||||||||||||||
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It is possible that, the quantitative difference of inoculated sporozoites is responsible for the difference observed in antibody recognition against MB2 between protected volunteers and persons living in endemic countries. | |||||||||||||||
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Since MB2 was shown to be present in multiple developmental stages including the hepatic stage that can be recognized by CTLs, it will be important to obtain evidence that MB2 also is recognized by CTLs from P. falciparum-exposed individuals. | |||||||||||||||
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It binds oxygen with an affinity between that of myoglobin and hemoglobin [3,4]. | |||||||||||||||
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In contrast, two regions of the acidic domain, one of which contains amino acid repeats, were recognized strongly by the antibodies in the endemic plasma (MB2-D & MB2-E). | |||||||||||||||
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Furthermore, antibodies from the serum of protected volunteers recognized preferentially the non-repeat-containing MB2-B peptide, while the repeat-containing MB2-C peptide is recognized preferentially by the antibodies in the plasma of persons living in malaria-endemic areas. | |||||||||||||||
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Immunoblot analyses using serum of a volunteer protected by the exposure to non-replicating metabolically active sporozoites (#5) revealed that linear epitopes within the basic domain of MB2 are recognized strongly, whilst the acidic domain is recognized poorly. | |||||||||||||||
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Sera from protected volunteers preferentially recognized a non-repeat region of the basic domain of MB2, whereas plasma from naturally-infected individuals also had antibodies that recognize regions of MB2 that contain a repeat motif in immunoblots. | |||||||||||||||
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Antibodies from protected volunteers preferentially recognized a non-repeat region of the basic domain of MB2, whereas plasma from naturally-infected individuals had antibodies that recognize regions of MB2 that contain a repeat motif. | |||||||||||||||
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It would appear that serum from this protected (#5) individual reacts preferentially with MB2-B (non-repeat containing) and to a lesser degree with the MB2-C (repeat containing) region. | |||||||||||||||
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Furthermore, antibodies from the serum of protected volunteers recognized preferentially the non-repeat-containing MB2-B peptide, while the repeat-containing MB2-C peptide is recognized preferentially by the antibodies in the plasma of persons living in malaria-endemic areas. | |||||||||||||||
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One of the striking observations is that protected volunteers were able to recognize preferentially the non-repeat MB2-B and to a lesser degree the repeat-including MB2-C and -D regions that most naturally exposed persons in malaria-endemic areas recognize. | |||||||||||||||
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Antibodies from protected volunteers preferentially recognized a non-repeat region of the basic domain of MB2, whereas plasma from naturally-infected individuals had antibodies that recognize regions of MB2 that contain a repeat motif. | |||||||||||||||
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Sera from protected volunteers preferentially recognized a non-repeat region of the basic domain of MB2, whereas plasma from naturally-infected individuals also had antibodies that recognize regions of MB2 that contain a repeat motif in immunoblots. | |||||||||||||||
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Formation of metmyoglobin has a maximal rate in meat where the partial oxygen pressure makes oxymyoglobin and myoglobin concentrations equal due to the dominating bimolecular electron transfer to oxygen to yield hydrogen peroxide:(183) | |||||||||||||||
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In Norway it was legal and a common practice until very recently to pack meat in an atmosphere with a low level of carbon monoxide, which binds very strongly to iron(II) myoglobin.(181) Carbonylmyoglobin is intensely red and does not oxidize to metmyoglobin under normal conditions, so the meat products have a remarkable color stability, which was appreciated in the country with its many remote and small societies and difficult transportation of foods. | |||||||||||||||
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Nitrites and nitrates are used in meat because they bind to myoglobin, inhibiting botulinum exotoxin production; however, they are powerful carcinogens (46). | |||||||||||||||
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