INT239500

Context Info Confidence 0.20 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.40 Pain Relevance 0.56

mitochondrion (Atic) nucleus (Aes)

Aes (Mus musculus) Atic (Mus musculus)

Pain Link Frequency Relevance Heat methotrexate 35 99.84 adenocard 14 97.16 Inflammation 4 85.64 antagonist 2 58.24 Central nervous system 3 53.12 central sensitization 1 34.24 agonist 2 5.00 Arthritis 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 15 99.60 INFLAMMATION 4 85.64 Vomiting 5 84.16 Ganglion Cysts 1 48.64 Panic Disorder 1 10.96 Anxiety Disorder 1 9.04 Toxicity 5 5.00 Disease 2 5.00 Arthritis 1 5.00 Headache 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While this is the first study of ADORA2a receptor polymorphisms in RA, others have shown associations between ATIC polymorphisms and AEs on MTX [14], specifically GI AEs [11] supporting the concept that the adenosine pathway is important in determining AEs on MTX.

AEs Binding (associations) of ATIC associated with adenocard, rheumatoid arthritis and methotrexate

1) Confidence 0.20 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.40 Pain Relevance 0.56

General Comments

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