INT239501

Context Info Confidence 0.24 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.95 Pain Relevance 0.64

mitochondrion (Mtx1) signal transduction (Adora2a) plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)

Adora2a (Mus musculus) Mtx1 (Mus musculus)

Pain Link Frequency Relevance Heat methotrexate 70 100.00 adenocard 28 100.00 Inflammation 8 63.08 agonist 4 61.48 antagonist 4 56.00 Arthritis 2 47.44 Central nervous system 6 5.00 central sensitization 2 5.00 headache 2 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 30 100.00 Disease 4 97.84 Toxicity 10 95.68 INFLAMMATION 8 63.08 Arthritis 2 47.44 Vomiting 10 5.00 Anxiety Disorder 2 5.00 Ganglion Cysts 2 5.00 Headache 2 5.00 Diarrhoea 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our aim was to examine the association between MTX outcomes in a well-characterized group of established RA patients and single nucleotide polymorphisms (SNPs) within the adenosine receptor 2a (ADORA2a) gene.

ADORA2a Spec (examine) Binding (association) of MTX associated with adenocard, rheumatoid arthritis and methotrexate

1) Confidence 0.24 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.64 Pain Relevance 0.57

Genetic variation within ADORA2a is significantly associated with AEs on MTX, specifically GI AEs.

ADORA2a Binding (associated) of MTX

2) Confidence 0.23 Published 2008 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2468887 Disease Relevance 0.30 Pain Relevance 0.07

General Comments

This test has worked.