INT239501

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtx1) signal transduction (Adora2a) plasma membrane (Adora2a)
enzyme binding (Adora2a) signal transducer activity (Adora2a)
Adora2a (Mus musculus)
Mtx1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 70 100.00 Very High Very High Very High
adenocard 28 100.00 Very High Very High Very High
Inflammation 8 63.08 Quite High
agonist 4 61.48 Quite High
antagonist 4 56.00 Quite High
Arthritis 2 47.44 Quite Low
Central nervous system 6 5.00 Very Low Very Low Very Low
central sensitization 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 30 100.00 Very High Very High Very High
Disease 4 97.84 Very High Very High Very High
Toxicity 10 95.68 Very High Very High Very High
INFLAMMATION 8 63.08 Quite High
Arthritis 2 47.44 Quite Low
Vomiting 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Ganglion Cysts 2 5.00 Very Low Very Low Very Low
Headache 2 5.00 Very Low Very Low Very Low
Diarrhoea 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our aim was to examine the association between MTX outcomes in a well-characterized group of established RA patients and single nucleotide polymorphisms (SNPs) within the adenosine receptor 2a (ADORA2a) gene.


ADORA2a Spec (examine) Binding (association) of MTX associated with adenocard, rheumatoid arthritis and methotrexate
1) Confidence 0.24 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.64 Pain Relevance 0.57
Genetic variation within ADORA2a is significantly associated with AEs on MTX, specifically GI AEs.
ADORA2a Binding (associated) of MTX
2) Confidence 0.23 Published 2008 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2468887 Disease Relevance 0.30 Pain Relevance 0.07

General Comments

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