INT239503

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.85
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2a) nucleus (Aes) plasma membrane (Adora2a)
enzyme binding (Adora2a) signal transducer activity (Adora2a)
Adora2a (Mus musculus)
Aes (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 105 99.84 Very High Very High Very High
adenocard 42 75.00 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
central sensitization 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 45 99.36 Very High Very High Very High
Toxicity 15 95.68 Very High Very High Very High
Disease 6 29.60 Quite Low
Anxiety Disorder 3 5.04 Very Low Very Low Very Low
Vomiting 15 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Headache 3 5.00 Very Low Very Low Very Low
Diarrhoea 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic variation within ADORA2a is significantly associated with AEs on MTX, specifically GI AEs.
ADORA2a Binding (associated) of AEs
1) Confidence 0.24 Published 2008 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2468887 Disease Relevance 0.30 Pain Relevance 0.07
Genetic variation within ADORA2a is significantly associated with AEs on MTX, specifically GI AEs.
ADORA2a Binding (associated) of AEs
2) Confidence 0.24 Published 2008 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2468887 Disease Relevance 0.30 Pain Relevance 0.07
In summary, we report a novel association between ADORA2a polymorphisms and AEs in MTX-treated RA patients.
ADORA2a Binding (association) of AEs associated with rheumatoid arthritis and methotrexate
3) Confidence 0.21 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.24 Pain Relevance 0.21

General Comments

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