INT239510

Context Info Confidence 0.02 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

endosome (Atp6v0a2) transport (Atp6v0a2) plasma membrane (Atp6v0a2) cytoplasm (Atp6v0a2)

Anatomy Link Frequency brain 1 Atp6v0a2 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 23 5.00 Morphine 19 5.00 Oxycodone 11 5.00 Opioid 6 5.00 positron emission tomography 4 5.00 Codeine 3 5.00 Gabapentin 2 5.00 agonist 2 5.00 Antihistamine 1 5.00 methadone 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 2 5.00 Decapitation 1 5.00 Confusion 1 5.00 Breast Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A Kp,uu of 0.5 indicates a maximal two-fold increase in brain ISF concentrations if all active efflux is blocked and a ratio of 0.1 will theoretically give a 10-fold increase.

Positive_regulation (increase) of ISF in brain

1) Confidence 0.02 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0

General Comments

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